TAK1-TABs complex: a central signalosome in inflammatory responses
YR Xu, CQ Lei - Frontiers in Immunology, 2021 - frontiersin.org
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK
kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of …
kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of …
Post-translational modifications of the TAK1-TAB complex
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the mitogen-
activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors …
activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors …
High-speed fluorescence image–enabled cell sorting
Fast and selective isolation of single cells with unique spatial and morphological traits
remains a technical challenge. Here, we address this by establishing high-speed image …
remains a technical challenge. Here, we address this by establishing high-speed image …
Type I interferon inhibits interleukin-1 production and inflammasome activation
Type I interferon (IFN) is a common therapy for autoimmune and inflammatory disorders, yet
the mechanisms of action are largely unknown. Here we showed that type I IFN inhibited …
the mechanisms of action are largely unknown. Here we showed that type I IFN inhibited …
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency
We report the clinical description and molecular dissection of a new fatal human inherited
disorder characterized by chronic autoinflammation, invasive bacterial infections and …
disorder characterized by chronic autoinflammation, invasive bacterial infections and …
Linear ubiquitin assembly complex negatively regulates RIG-I-and TRIM25-mediated type I interferon induction
Upon detection of viral RNA, retinoic acid-inducible gene I (RIG-I) undergoes TRIM25-
mediated K63-linked ubiquitination, leading to type I interferon (IFN) production. In this …
mediated K63-linked ubiquitination, leading to type I interferon (IFN) production. In this …
The membrane-associated MARCH E3 ligase family: emerging roles in immune regulation
H Lin, S Li, HB Shu - Frontiers in Immunology, 2019 - frontiersin.org
The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases
have emerged as critical regulators of immune responses. MARCH proteins target immune …
have emerged as critical regulators of immune responses. MARCH proteins target immune …
Linear polyubiquitination: a new regulator of NF‐κB activation
K Iwai, F Tokunaga - EMBO reports, 2009 - embopress.org
The ubiquitin‐conjugation system regulates a vast range of biological phenomena by
affecting protein function mostly through polyubiquitin conjugation. The type of polyubiquitin …
affecting protein function mostly through polyubiquitin conjugation. The type of polyubiquitin …
TRIM38 inhibits TNFα-and IL-1β–triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3
TNFα and IL-1β are two proinflammatory cytokines that play critical roles in many diseases,
including rheumatoid arthritis and infectious diseases. How TNFα-and IL-1β–mediated …
including rheumatoid arthritis and infectious diseases. How TNFα-and IL-1β–mediated …
miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling
M Hart, B Walch-Rückheim, KS Friedmann… - Cell death & …, 2019 - nature.com
NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional
regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB …
regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB …