Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses

KL Hilligan, F Ronchese - Cellular & molecular immunology, 2020 - nature.com
Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

[HTML][HTML] Recent advances in understanding the Th1/Th2 effector choice

MJ Butcher, J Zhu - Faculty reviews, 2021 - ncbi.nlm.nih.gov
For over 35 years since Mosmann and Coffman proposed the seminal “type 1 T helper
(Th1)/type 2 T helper (Th2)” hypothesis in 1986, the immunological community has …

Schistosome egg migration: mechanisms, pathogenesis and host immune responses

AH Costain, AS MacDonald, HH Smits - Frontiers in immunology, 2018 - frontiersin.org
Many parasitic worms possess complex and intriguing life cycles, and schistosomes are no
exception. To exit the human body and progress to their successive snail host, Schistosoma …

Lessons learned and unlearned in periodontal microbiology

R Teles, F Teles, J Frias‐Lopez, B Paster… - Periodontology …, 2013 - Wiley Online Library
Periodontal diseases are initiated by bacterial species living in polymicrobial biofilms at or
below the gingival margin and progress largely as a result of the inflammation elicited by …

Dendritic-cell control of pathogen-driven T-cell polarization

ML Kapsenberg - Nature Reviews Immunology, 2003 - nature.com
Dendritic cells (DCs) are central in the orchestration of the various forms of immunity and
tolerance. Their immunoregulatory role mainly relies on the ligation of specific receptors that …

The immunobiology of schistosomiasis

EJ Pearce, AS MacDonald - Nature Reviews Immunology, 2002 - nature.com
Schistosomes are parasitic worms that are a prime example of a complex multicellular
pathogen that flourishes in the human host despite the development of a pronounced …

Allergy, parasites, and the hygiene hypothesis

M Yazdanbakhsh, PG Kremsner, R Van Ree - Science, 2002 - science.org
The increase of allergic diseases in the industrialized world has often been explained by a
decline in infections during childhood. The immunological explanation has been put into the …

Immune regulation by helminth parasites: cellular and molecular mechanisms

RM Maizels, M Yazdanbakhsh - Nature Reviews Immunology, 2003 - nature.com
Immunology was founded by studying the body's response to infectious microorganisms,
and yet microbial prokaryotes only tell half the story of the immune system. Eukaryotic …

DC-SIGN: escape mechanism for pathogens

Y van Kooyk, TBH Geijtenbeek - Nature Reviews Immunology, 2003 - nature.com
Dendritic cells (DCs) are crucial in the defence against pathogens. Invading pathogens are
recognized by Toll-like receptors (TLRs) and receptors such as C-type lectins expressed on …

[HTML][HTML] Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

D Amsen, JM Blander, GR Lee, K Tanigaki, T Honjo… - Cell, 2004 - cell.com
Antigen-presenting cells (APC) tailor immune responses to microbial encounters by
stimulating differentiation of CD4 T cells into the Th1 and Th2 lineages. We demonstrate that …