Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

Invertebrate models have generated many new insights into transmembrane signaling by
cell-surface receptors. This review focuses on receptor guanylyl cyclases (rGCs) and …

Most eukaryotic cells express small regulatory RNAs. The purpose of one class, the somatic
endogenous siRNAs (endo-siRNAs), remains unclear. Here, we show that the endo-siRNA …

The ability to detect and respond to acute oxygen (O2) shortages is indispensable to aerobic
life. The molecular mechanisms and circuits underlying this capacity are poorly understood …

Sensory experience modifies behavior through both associative and non-associative
learning. In Caenorhabditis elegans, pairing odor with food deprivation results in aversive …

Abstract cGMP plays a role in sensory signaling and plasticity by regulating ion channels,
phosphodiesterases, and kinases. Studies that primarily used genetic and biochemical tools …

Identifying the environmental information and computations that drive sensory detection is
key for understanding animal behavior. Using experimental and theoretical analysis of AWC …

Primary (non-motile) cilia represent structurally and functionally diverse organelles whose
roles as specialized cellular antenna are central to animal cell signaling pathways, sensory …

Cyclic guanosine monophosphate (cGMP) plays a crucial role as a second messenger in
the regulation of sensory signal transduction in many organisms. In AWC olfactory sensory …

The extent to which behavior is shaped by experience varies between individuals. Genetic
differences contribute to this variation, but the neural mechanisms are not understood. Here …