The central role of the cardiovascular system is to maintain adequate capillary perfusion.
The spatially and temporally heterogeneous nature of capillary perfusion has been reported …

In this review, we present a discussion of diabetes and its complications, including the
macrovascular and microvascular effects, with the latter of consequence to the retina. We …

The prevalence of high childhood blood pressure (BP) is rising globally and has been
associated with subclinical vascular impairments in children. Longitudinal data on the …

We investigated and compared the susceptibility of retinal blood flow regulation and neural
function in mice developing type 2 diabetes. The longitudinal changes in retinal neuronal …

The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include
cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway …

Increased arterial stiffness and vascular remodeling precede and are consequences of
hypertension. They also contribute to the development and progression of life-threatening …

Diabetic macular oedema (DMO) is one of the leading causes of vision loss associated with
diabetic retinopathy (DR). New insights in managing this condition have changed the …

Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction,
affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable …

Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells
(RGCs), the output neurons of the retina. Multiple lines of evidence show the endothelin …

Retinitis pigmentosa (RP) and macular dystrophy (MD) are characterized by gradual
photoreceptor death in the retina and are often associated with genetic mutations, including …