Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Humans in modern societies typically consume food at least three times daily, while
laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns …

Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated
diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings …

Abstract Background The cJun-N-terminal-kinase (JNK) plays a central role in the cell stress
response, with outcomes ranging from cell death to cell proliferation and survival, depending …

Background Host-microbe associations underlie many key processes of host development,
immunity, and life history. Yet, none of the current research on the central model species …

Genetic and pharmacological interventions have successfully extended healthspan and
lifespan in animals, but their genetic interventions are not appropriate options for human …

Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …

The molecular mechanisms underlying the aging process have garnered much attention in
recent decades because aging is the most significant risk factor for many chronic diseases …

As the population ages, promoting healthy aging through targeted interventions becomes
increasingly crucial. Growing evidence suggests that dietary interventions can significantly …

Aging is a natural process accompanied by a progressive accumulation of damage in all
constituent macromolecules (nucleic acids, lipids and proteins). Accumulation of damage in …