The establishment of in vitro models of the BBB is significant for the evaluation of the
mechanism and permeability of drugs and their sustained-release formulations across the …

Brain cancer remains the deadliest cancer. The blood–brain barrier (BBB) is impenetrable to
most drugs and is a complex 3D network of multiple cell types including endothelial cells …

Background Preserving the integrity of the blood-brain barrier (BBB) is beneficial to avoid
further brain damage after acute ischemic stroke (AIS). Astrocytes, an important component …

The blood brain barrier (BBB) and blood tumour barrier (BTB) remain a major roadblock for
delivering therapies to treat brain cancer. Amongst brain cancers, glioblastoma (GBM) is …

The blood-brain barrier (BBB) serves to protect and regulate the CNS microenvironment.
The development of an in-vitro mimic of the BBB requires recapitulating the correct …

The brain is a complex organ protected by the blood-brain barrier (BBB), which also has a
complex organization. To play its protective role, the BBB acts by limiting the paracellular …

Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for
many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis …

Direct Oral Anticoagulants (DOACs) have simplified the treatment of thromboembolic
disease. In addition to their established anticoagulant effects, there are indications from …

Exposure to radiation during the treatment of CNS tumors leads to detrimental damage of
the blood brain barrier (BBB) in normal tissue. Effects are characterized by leakage of the …

The development of an in vitro model for predicting drug permeability through the human
blood–brain barrier (BBB) will greatly accelerate the development of neural therapy …