The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

GD Brown - Molecules, 2010 - mdpi.com
The Chinese medicinal plant Artemisia annua L.(Qinghao) is the only known source of the
sesquiterpene artemisinin (Qinghaosu), which is used in the treatment of malaria …

Development of anticancer agents from plant-derived sesquiterpene lactones

Y Ren, J Yu, A Douglas Kinghorn - Current medicinal chemistry, 2016 - ingentaconnect.com
Sesquiterpene lactones are of considerable interest due to their potent bioactivities,
including cancer cell cytotoxicity and antineoplastic efficacy in in vivo studies. Among these …

Artemisinin-passivated mixed-cation perovskite films for durable flexible perovskite solar cells with over 21% efficiency

L Yang, Q Xiong, Y Li, P Gao, B Xu, H Lin… - Journal of Materials …, 2021 - pubs.rsc.org
High power conversion efficiencies (PCEs) surpassing 20% have been achieved on flexible
single-junction perovskite solar cells recently. However, improvements of the open-circuit …

Controlled Oxidation of Remote sp3 C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity

K Zhang, BM Shafer, MD Demars… - Journal of the …, 2012 - ACS Publications
The selective oxyfunctionalization of isolated sp3 C–H bonds in complex molecules
represents a formidable challenge in organic chemistry. Here, we describe a rational …

Structure− Activity Relationships of the Antimalarial Agent Artemisinin. 8. Design, Synthesis, and CoMFA Studies toward the Development of Artemisinin-Based Drugs …

MA Avery, KM Muraleedharan, PV Desai… - Journal of Medicinal …, 2003 - ACS Publications
Artemisinin (1) and its analogues have been well studied for their antimalarial activity. Here
we present the antimalarial activity of some novel C-9-modified artemisinin analogues …

Phytochemical analysis of a herbal tea from Artemisia annua L.

T Carbonara, R Pascale, MP Argentieri… - … of pharmaceutical and …, 2012 - Elsevier
Strategies to control diffusion of malaria needs to account for the increase of resistance of
the parasite to the conventional antimalarial drugs. It has been proposed that a traditional …

Drug–polymer compatibility prediction via COSMO-RS

A Mathers, M Fulem - International Journal of Pharmaceutics, 2024 - Elsevier
In this work, the solid–liquid equilibrium (SLE) curve for ten active pharmaceutical
ingredients (APIs) with the polymer polyvinylpyrrolidone (PVP) K12 was purely predicted …

Structure− activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR …

MA Avery, M Alvim-Gaston, CR Rodrigues… - Journal of medicinal …, 2002 - ACS Publications
Artemisinin (1) is a unique sesquiterpene peroxide occurring as a constituent of Artemisia
annua L. Because of the effectiveness of Artemisinin in the treatment of drug-resistant …

Regulation of artemisinin and its derivatives on the assembly behavior and cytotoxicity of amyloid polypeptides hIAPP and Aβ

J Xu, C Zhao, X Huang, W Du - ACS Chemical Neuroscience, 2019 - ACS Publications
The misfolding and aggregation of human islet amyloid polypeptide (hIAPP) and amyloid-β
(Aβ) protein are closely associated with type 2 diabetes mellitus (T2DM) and Alzheimer's …

Screening of new solvents for artemisinin extraction process using ab initio methodology

AA Lapkin, M Peters, L Greiner, S Chemat… - Green …, 2010 - pubs.rsc.org
The solubility of artemisinin in a range of conventional and novel solvents was evaluated
using the COSMO-RS approach, and verified experimentally as well as against literature …