Platelets are central to inflammation-related manifestations of cardiovascular diseases
(CVD) such as atherosclerosis. Platelet-activating factor (PAF), thrombin, thromboxane A 2 …

Atherosclerosis is a chronic inflammatory disease that is characterized by the formation of
lipid rich plaques in the wall of medium to large sized arteries. Atherothrombosis represents …

The concept of platelets as important players in the process of atherogenesis has become
increasingly accepted due to accumulating experimental and clinical evidence. Despite the …

Activation of the blood coagulation cascade leads to fibrin deposition and platelet activation
that are required for hemostasis. However, aberrant activation of coagulation can lead to …

Background Variations in the blood coagulation activity, determined genetically or by
medication, may alter atherosclerotic plaque progression, by influencing pleiotropic effects …

Warfarin has been utilized for decades as an effective anticoagulant in patients with a history
of strong risk factors for venous thromboembolism (VTE). Established adverse effects …

Vitamin K-antagonists (VKA) are the most widely used anticoagulant drugs to treat patients
at risk of arterial and venous thrombosis for the past 50 years. Due to unfavorable …

Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with
important vascular and hemostatic alterations that should be taken into account during …

Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide.
Therefore, there is interest in the search for cardiovascular risk markers that contribute to the …

Thrombin is a key enzyme in hemostasis and thrombosis, regulating pro-and anticoagulant
reactions by interacting with other coagulation proteins and cellular receptors. 1 Thrombin …