First-line immunotherapy for non–small-cell lung cancer

M Reck, J Remon, MD Hellmann - Journal of Clinical Oncology, 2022 - ingentaconnect.com
For patients with metastatic non–small-cell lung cancer (mNSCLC), the last decade has
been characterized by critical progress that has contributed to substantially improved …

[HTML][HTML] KRAS mutation: from undruggable to druggable in cancer

L Huang, Z Guo, F Wang, L Fu - Signal transduction and targeted …, 2021 - nature.com
Cancer is the leading cause of death worldwide, and its treatment and outcomes have been
dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene …

Pembrolizumab versus placebo as adjuvant therapy for completely resected stage IB–IIIA non-small-cell lung cancer (PEARLS/KEYNOTE-091): an interim analysis of …

M O'Brien, L Paz-Ares, S Marreaud, U Dafni… - The Lancet …, 2022 - thelancet.com
Background Pembrolizumab is a standard-of-care for advanced non-small-cell lung cancer
(NSCLC). We assessed pembrolizumab as adjuvant therapy for completely resected stage …

Non‐small cell lung cancer in China

P Chen, Y Liu, Y Wen, C Zhou - Cancer Communications, 2022 - Wiley Online Library
In China, lung cancer is a primary cancer type with high incidence and mortality. Risk factors
for lung cancer include tobacco use, family history, radiation exposure, and the presence of …

Toward personalized treatment approaches for non-small-cell lung cancer

M Wang, RS Herbst, C Boshoff - Nature medicine, 2021 - nature.com
Worldwide, lung cancer is the most common cause of cancer-related deaths. Molecular
targeted therapies and immunotherapies for non-small-cell lung cancer (NSCLC) have …

Pembrolizumab in patients with microsatellite instability–high advanced endometrial cancer: results from the KEYNOTE-158 study

DM O'Malley, GM Bariani, PA Cassier… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Pembrolizumab demonstrated durable antitumor activity in patients with
previously treated, advanced microsatellite instability–high or mismatch repair–deficient …

Durvalumab with or without tremelimumab in combination with chemotherapy as first-line therapy for metastatic non–small-cell lung cancer: the phase III POSEIDON …

ML Johnson, BC Cho, A Luft… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE The open-label, phase III POSEIDON study evaluated tremelimumab plus
durvalumab and chemotherapy (T+ D+ CT) and durvalumab plus chemotherapy (D+ CT) …

Sintilimab plus a bevacizumab biosimilar (IBI305) versus sorafenib in unresectable hepatocellular carcinoma (ORIENT-32): a randomised, open-label, phase 2–3 …

Z Ren, J Xu, Y Bai, A Xu, S Cang, C Du, Q Li… - The Lancet …, 2021 - thelancet.com
Background China has a high burden of hepatocellular carcinoma, and hepatitis B virus
(HBV) infection is the main causative factor. Patients with hepatocellular carcinoma have a …

[PDF][PDF] Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer

NS Patil, BY Nabet, S Müller, H Koeppen, W Zou… - Cancer cell, 2022 - cell.com
Inhibitors of the programmed cell death-1 (PD-1/PD-L1) signaling axis are approved to treat
non-small cell lung cancer (NSCLC) patients, based on their significant overall survival (OS) …

[HTML][HTML] Five-year outcomes with pembrolizumab versus chemotherapy for metastatic non–small-cell lung cancer with PD-L1 tumor proportion score≥ 50%

M Reck, D Rodríguez-Abreu, AG Robinson… - Journal of Clinical …, 2021 - ncbi.nlm.nih.gov
Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non–Small-Cell
Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50% - PMC Back to Top Skip to main …