Viral hepatitis C

S Sherlock - Current opinion in Gastroenterology, 1993 - journals.lww.com
The original hepatitis C virus antibody test against the C100 antigen has been replaced by a
second-generation recombinant immunoblot assay that detects antibodies against four viral …

Persistent hepatitis C viraemia without liver disease

S Brillanti, M Foli, S Gaiani, C Masci, M Miglioli… - The Lancet, 1993 - Elsevier
In viral infections persistence of the virus is not always associated with virus-induced
disease. To find out if active hepatitis C virus (HCV) infection can persist without liver …

Microarray profiling of antiviral antibodies for the development of diagnostics, vaccines, and therapeutics

HEN de Vegvar, WH Robinson - Clinical Immunology, 2004 - Elsevier
Multiplex analysis of antiviral antibody (Ab) responses provides a potentially powerful
strategy for viral diagnosis, prognostication, and development of vaccines and prophylactic …

HCV replication in mononuclear cells stimulates anti‐HCV‐secreting B cells and reflects nonresponsiveness to interferon‐α

HF Lohr, B Goergen… - Journal of medical …, 1995 - Wiley Online Library
Recently, it was demonstrated in chronic hepatitis C that the release of IgG and IgM anti‐
HCV antibodies by mononuclear cells (PBMCs) correlated with inflammatory activity, HCV …

Immunoglobulin G antibody avidity assay for serodiagnosis of hepatitis C virus infection

A Kanno, Y Kazuyama - Journal of medical virology, 2002 - Wiley Online Library
It has been reported that the avidity of specific IgG antibody is lower in primary viral infection
than in chronic viral infection. However, few studies have been reported on the IgG avidity in …

Distinguishing acute from chronic and resolved hepatitis C virus (HCV) infections by measurement of anti-HCV immunoglobulin G avidity index

S Klimashevskaya, A Obriadina… - Journal of Clinical …, 2007 - Am Soc Microbiol
An assay to measure avidity index (AI) was developed to diagnose incident hepatitis C virus
(HCV) infections. The assay demonstrated an AI value statistically significantly lower in …

Mode of hepatitis C virus infection, epidemiology, and chronicity rate in the general population and risk groups

HL Tillmann, MP Manns - Digestive diseases and sciences, 1996 - Springer
Since the discovery of the hepatitis C virus (HCV), it has become evident that this infectious
agent is a primary cause of posttransfusion and sporadic non-A, non-B hepatitis …

Interferon therapy in chronic hepatitis C virus infection

O Weiland - FEMS microbiology reviews, 1994 - academic.oup.com
Antiviral treatment of chronic hepatitis C with interferon is reviewed. Alpha-interferon, both
recombinant alpha-2a,-2b and human lymphoblastoid interferon given at a dose of≥ 3MU …

The significance of immunoglobulin M antibody response to hepatitis C virus core protein in patients with chronic hepatitis C

N Yuki, N Hayashi, K Ohkawa, H Hagiwara, M Oshita… - Hepatology, 1995 - journals.lww.com
The significance of immunoglobulin (Ig) M antibody to hepatitis C virus core protein (IgM anti-
HCVcore) was studied in 41 patients with chronic hepatitis C virus (HCV) infection …

Liver‐infiltrating and circulating CD4+ T cells in chronic hepatitis C: immunodominant epitopes, HLA‐restriction and functional significance

HF Löhr, JF Schlaak, S Kollmannsperger, HP Dienes… - Liver, 1996 - Wiley Online Library
The aim was to assess the specificity and functional significance of liver‐infiltrating and
peripheral blood T cells in chronic hepatitis C. Peripheral blood mononuclear cells hepatitis …