Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
Systems biology of cancer metastasis
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …
Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer
X Zheng, X Wang, X Cheng, Z Liu, Y Yin, X Li, Z Huang… - Nature Cancer, 2023 - nature.com
Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with
widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC …
widespread metastases and ascites. Here, we depicted a single-cell landscape of the OC …
Integrated proteogenomic characterization of human high-grade serous ovarian cancer
To provide a detailed analysis of the molecular components and underlying mechanisms
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …
associated with ovarian cancer, we performed a comprehensive mass-spectrometry-based …
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer
DD Bowtell, S Böhm, AA Ahmed, PJ Aspuria… - Nature reviews …, 2015 - nature.com
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …
and overall survival has not changed significantly for several decades. In this Opinion article …
Exosomes promote pre-metastatic niche formation in ovarian cancer
W Feng, DC Dean, FJ Hornicek, H Shi, Z Duan - Molecular cancer, 2019 - Springer
Ovarian cancer is one of the most common gynecological malignancies. Upon initial
diagnosis, the majority of patients present with widespread metastatic growth within the …
diagnosis, the majority of patients present with widespread metastatic growth within the …
IL-6 and ovarian cancer: inflammatory cytokines in promotion of metastasis
L Browning, MR Patel, EB Horvath… - Cancer management …, 2018 - Taylor & Francis
Ovarian cancer is the most fatal gynecological cancer in the USA and the fifth most common
cancer-related cause of death in women. Inflammation has been shown to play many roles …
cancer-related cause of death in women. Inflammation has been shown to play many roles …
Tumor-associated macrophages drive spheroid formation during early transcoelomic metastasis of ovarian cancer
M Yin, X Li, S Tan, HJ Zhou, W Ji… - The Journal of …, 2016 - Am Soc Clin Investig
Tumor-associated macrophages (TAMs) can influence ovarian cancer growth, migration,
and metastasis, but the detailed mechanisms underlying ovarian cancer metastasis remain …
and metastasis, but the detailed mechanisms underlying ovarian cancer metastasis remain …
Immunological functions of the omentum
S Meza-Perez, TD Randall - Trends in immunology, 2017 - cell.com
The omentum is a visceral adipose tissue with unique immune functions. Although it is
primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky …
primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky …
Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance
Adipocytes are critical for ovarian cancer cells to home to the omentum, but the metabolic
changes initiated by this interaction are unknown. To this end, we carried out unbiased mass …
changes initiated by this interaction are unknown. To this end, we carried out unbiased mass …