Along with rapid advances in human genomics, policies governing genomic data and
clinical technologies have proliferated. Stakeholder engagement is widely lauded as an …

Background Whole-exome sequencing (WES) consists in the capture, sequencing and
analysis of all exons in the human genome. Originally developed in the research context …

As more research studies incorporate next-generation sequencing (including whole-
genome or whole-exome sequencing), investigators and institutional review boards face …

Abstract Purpose The American College of Medical Genetics and Genomics (ACMG)
recommended that clinical laboratories performing next-generation sequencing analyze and …

Professional recommendations for the return of results from exome and whole-genome
sequencing (ES/WGS) have been controversial. The lack of clear guidance about whether …

As genomic science has evolved, so have policy and practice debates about how to
describe and evaluate the ways in which genomic information is treated for individuals …

This paper summarizes the current controversies surrounding the identification and
disclosure of “incidental” or “secondary” findings from genomic sequencing and the …

Genomic research—including whole genome sequencing and whole exome sequencing—
has a growing presence in contemporary biomedical investigation. The capacity of …

New genomic sequencing technologies enable the high-speed analysis of multiple genes
simultaneously, including all of those in a person's genome. Sequencing is a prominent …

Purpose Proposals to return medically actionable secondary genetic findings (SFs) in the
clinical and research settings have generated controversy regarding whether to solicit …