[HTML][HTML] Stakeholder engagement in policy development: challenges and opportunities for human genomics
AA Lemke, JN Harris-Wai - Genetics in Medicine, 2015 - Elsevier
Along with rapid advances in human genomics, policies governing genomic data and
clinical technologies have proliferated. Stakeholder engagement is widely lauded as an …
clinical technologies have proliferated. Stakeholder engagement is widely lauded as an …
Unsolved challenges of clinical whole-exome sequencing: a systematic literature review of end-users' views
Background Whole-exome sequencing (WES) consists in the capture, sequencing and
analysis of all exons in the human genome. Originally developed in the research context …
analysis of all exons in the human genome. Originally developed in the research context …
Return of genomic results to research participants: the floor, the ceiling, and the choices in between
GP Jarvik, LM Amendola, JS Berg, K Brothers… - The American Journal of …, 2014 - cell.com
As more research studies incorporate next-generation sequencing (including whole-
genome or whole-exome sequencing), investigators and institutional review boards face …
genome or whole-exome sequencing), investigators and institutional review boards face …
[HTML][HTML] The cost-effectiveness of returning incidental findings from next-generation genomic sequencing
CS Bennette, CJ Gallego, W Burke, GP Jarvik… - Genetics in …, 2015 - Elsevier
Abstract Purpose The American College of Medical Genetics and Genomics (ACMG)
recommended that clinical laboratories performing next-generation sequencing analyze and …
recommended that clinical laboratories performing next-generation sequencing analyze and …
Attitudes of genetics professionals toward the return of incidental results from exome and whole-genome sequencing
JH Yu, TM Harrell, SM Jamal, HK Tabor… - The American Journal of …, 2014 - cell.com
Professional recommendations for the return of results from exome and whole-genome
sequencing (ES/WGS) have been controversial. The lack of clear guidance about whether …
sequencing (ES/WGS) have been controversial. The lack of clear guidance about whether …
Genomic contextualism: shifting the rhetoric of genetic exceptionalism
NA Garrison, KB Brothers, AJ Goldenberg… - The American Journal …, 2019 - Taylor & Francis
As genomic science has evolved, so have policy and practice debates about how to
describe and evaluate the ways in which genomic information is treated for individuals …
describe and evaluate the ways in which genomic information is treated for individuals …
Incidental findings with genomic testing: implications for genetic counseling practice
MI Roche, JS Berg - Current genetic medicine reports, 2015 - Springer
This paper summarizes the current controversies surrounding the identification and
disclosure of “incidental” or “secondary” findings from genomic sequencing and the …
disclosure of “incidental” or “secondary” findings from genomic sequencing and the …
Models of consent to return of incidental findings in genomic research
PS Appelbaum, E Parens, CR Waldman… - Hastings Center …, 2014 - Wiley Online Library
Genomic research—including whole genome sequencing and whole exome sequencing—
has a growing presence in contemporary biomedical investigation. The capacity of …
has a growing presence in contemporary biomedical investigation. The capacity of …
Genomic sequencing: assessing the health care system, policy, and big-data implications
KA Phillips, JR Trosman, RK Kelley, MJ Pletcher… - Health …, 2014 - healthaffairs.org
New genomic sequencing technologies enable the high-speed analysis of multiple genes
simultaneously, including all of those in a person's genome. Sequencing is a prominent …
simultaneously, including all of those in a person's genome. Sequencing is a prominent …
Exploring the motivations of research participants who chose not to learn medically actionable secondary genetic findings about themselves
Purpose Proposals to return medically actionable secondary genetic findings (SFs) in the
clinical and research settings have generated controversy regarding whether to solicit …
clinical and research settings have generated controversy regarding whether to solicit …