Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade
MA Stanczak, N Rodrigues Mantuano… - Science translational …, 2022 - science.org
Immune checkpoint blockade (ICB) has substantially improved the prognosis of patients with
cancer, but the majority experiences limited benefit, supporting the need for new therapeutic …
cancer, but the majority experiences limited benefit, supporting the need for new therapeutic …
[HTML][HTML] Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses
G Wu, G Murugesan, M Nagala, A McCraw… - Wellcome Open …, 2021 - ncbi.nlm.nih.gov
Background: Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-
dependent cellular interactions. Its upregulation on macrophages in autoimmune disease …
dependent cellular interactions. Its upregulation on macrophages in autoimmune disease …