Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review

W Wang, H Zhou, L Liu - European journal of medicinal chemistry, 2018 - Elsevier
Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs
(DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability …

[HTML][HTML] Overview of methotrexate toxicity: a comprehensive literature review

KM Hamed, IM Dighriri, AF Baomar, BT Alharthy… - Cureus, 2022 - ncbi.nlm.nih.gov
Methotrexate (MTX) is significantly more effective than and has a considerable advantage
over placebo in patients with severe and persistent rheumatoid arthritis (RA). The drug is …

2016 update of the EULAR recommendations for the management of early arthritis

B Combe, R Landewe, CI Daien, C Hua… - Annals of the …, 2017 - ard.bmj.com
Objectives Since the 2007 recommendations for the management of early arthritis have
been presented, considerable research has been published in the field of early arthritis …

Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

D Ezhilarasan - Toxicology, 2021 - Elsevier
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

2022 EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in adults with autoimmune inflammatory rheumatic diseases

GE Fragoulis, E Nikiphorou, M Dey, SS Zhao… - Annals of the …, 2023 - ard.bmj.com
Objectives To develop EULAR recommendations for screening and prophylaxis of chronic
and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases …

A systematic review of Internet‐based supportive interventions for caregivers of patients with dementia

LMM Boots, ME de Vugt… - … journal of geriatric …, 2014 - Wiley Online Library
Objective Because of the expected increase in the number of dementia patients, the
unlikelihood of a cure in the near future, and the rising cost of care, there is an increasing …

[HTML][HTML] Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research

C Salliot, D van der Heijde - Annals of the rheumatic diseases, 2009 - ard.bmj.com
Objective: To perform a systematic literature review of the long-term safety of methotrexate
(MTX) monotherapy in rheumatoid arthritis (RA). Methods: A search was performed in …

Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad …

F Sivera, M Andrés, L Carmona, ASR Kydd… - Annals of the …, 2014 - ard.bmj.com
We aimed to develop evidence-based multinational recommendations for the diagnosis and
management of gout. Using a formal voting process, a panel of 78 international …

Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics

K Pietrzik, L Bailey, B Shane - Clinical pharmacokinetics, 2010 - Springer
There is a large body of evidence to suggest that improving periconceptional folate status
reduces the risk of neonatal neural tube defects. Thus increased folate intake is now …

Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial

MF Bakker, JWG Jacobs, PMJ Welsing… - Annals of internal …, 2012 - acpjournals.org
Background: Treatment strategies for tight control of early rheumatoid arthritis (RA) are
highly effective but can be improved. Objective: To investigate whether adding prednisone …