Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

Alcohol use disorders consist of disorders characterised by compulsive heavy alcohol use
and loss of control over alcohol intake. Alcohol use disorders are some of the most prevalent …

Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …

Excessive alcohol use is the cause of an ongoing public health crisis, and accounts for~ 5%
of global disease burden. A minority of people with recreational alcohol use develop alcohol …

Astrocytes are fundamental building blocks of the central nervous system. Their dysfunction
has been implicated in many psychiatric disorders, including alcohol use disorder, yet our …

Excessive alcohol consumption remains a global public health crisis, with millions suffering
from alcohol use disorder (AUD, or simply “alcoholism”), leading to significantly reduced life …

Cue-reward associations form distinct memories that can drive appetitive behaviors and are
involved in craving for both drugs and natural rewards. Distinct sets of neurons, so-called …

Adolescents primarily consume alcohol in binges, which can be particularly harmful to the
developing frontal cortex and increase risk for an adult alcohol use disorder. We conducted …

Incentive salience, negative emotionality, and executive function are functional domains that
are etiologic in the initiation and progression of addictive disorders, having been implicated …

Noncoding RNAs (ncRNAs) represent the majority of the transcriptome and play important
roles in regulating neuronal functions. ncRNAs are exceptionally diverse in both structure …