Vertebrate hemoglobin (Hb) and myoglobin (Mb) were among the first proteins whose
structures and sequences were determined over 50 years ago. In the subsequent …

Chronic viral hepatitis B and C and non-alcoholic fatty liver disease (NAFLD) have been
widely acknowledged to be the leading causes of liver cirrhosis and hepatocellular …

Significance: Cytoglobin (Cygb) was discovered as a new addition to the globin superfamily
and subsequently identified to have potent nitric oxide (NO) dioxygenase function. Cygb …

Pancreatic cancer is a highly challenging malignancy with extremely poor prognosis.
Cytoglobin (CYGB), a hemeprotein involved in liver fibrosis and cancer development, is …

Background & Aims Cytoglobin (CYGB) is a respiratory protein that acts as a scavenger of
reactive oxygen species. The molecular role of CYGB in human hepatic stellate cell (HSC) …

Cytoglobin is an evolutionary ancient hemoglobin with poor functional annotation. Rather
than constrained to penta coordination, cytoglobin's heme iron may exist either as a penta or …

Background and Aims Antifibrotic therapy remains an unmet medical need in human chronic
liver disease. We report the antifibrotic properties of cytoglobin (CYGB), a respiratory protein …

Cytoglobin (Cygb) is an evolutionary ancient heme protein with yet unclear physiological
function (s). Mammalian Cygb is ubiquitously expressed in all tissues and is proposed to be …

Cytoglobin (Cygb), a stellate cell-specific globin, has recently drawn attention due to its
association with liver fibrosis. In the livers of both humans and rodents, Cygb is expressed …

Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver
fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into …