Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

The purpose of this review is to provide an account of the physiological substrates of cAMP-
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …

Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

Objectives: We sought to evaluate the role of exercise-related changes in left ventricular (LV)
relaxation and of LV contractile function and vasculoventricular coupling (VVC) in the …

Phosphorylation of cardiac myofibrils by cAMP-dependent protein kinase (PKA) can
increase the intrinsic rate of myofibrillar relaxation, which may contribute to the shortening of …

Abstract Cardiac troponin (Tn) I (CTnI), compared with skeletal TnI, contains extra amino
acids (32 to 33) at its amino terminus, including two adjacent serine residues. These two …

▪ Abstract Although well known as the location of the mechanism by which the cardiac
sarcomere is activated by Ca2+ to generate force and shortening, the thin filament is now …

We present a current perception of the regulation of activation of cardiac myofilaments with
emphasis on troponin (Tn) and tropomyosin (Tm). Activation involves both a Ca2+-regulated …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Troponin is the regulatory complex of the myofibrillar thin filament that plays a critical role in
regulating excitation-contraction coupling in the heart. Troponin is composed of three distinct …