The clinical phenotype of heterozygous familial hypercholesterolemia (FH) is characterized
by increased plasma levels of total cholesterol and low density lipoprotein cholesterol …

Familial hypercholesterolaemia (FH) is an autosomal dominant genetic disorder, associated
with elevated levels of low-density lipoprotein-cholesterol (LDL-C), which can lead to …

Atherogenic low density lipoproteins are cleared from the circulation by hepatic low density
lipoprotein receptors (LDLR). Two inherited forms of hypercholesterolemia result from loss of …

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated
endocytosis, simultaneously binding both clathrin and receptors. This dual interaction …

For many years, the low-density lipoprotein (LDL) receptor and the LDL receptor-related
protein (LRP) have been considered to be prototypes of cargo receptors which deliver, via …

Familial Hypercholesterolemia (FH) is a common cause of premature cardiovascular
disease and is often undiagnosed in young people. Although the disease is diagnosed …

The most frequent form of monogenic hypercholesterolemia, also known as Familial
Hypercholesterolemia (FH), is characterized by plasma accumulation of cholesterol …

The recent characterization of a rare genetic defect causing autosomal recessive
hypercholesterolemia (ARH) has provided new insights into the underlying mechanism of …

Familial hypercholesterolemia (FH), a frequent monogenic condition complicated by
premature cardiovascular disease, is characterized by high allelic heterogeneity at the low …

Gallbladder disease (GBD) is one of the major digestive diseases. Its risk factors include
age, sex, obesity, type 2 diabetes, and metabolic syndrome (MS). The prevalence of GBD is …