Members of the major facilitator superfamily (MFS) of transport proteins are essential for the
movement of a wide range of substrates across biomembranes. As this transport requires a …

Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

For many years, amino acid‐specific covalent labeling has been a valuable tool to study
protein structure and protein interactions, especially for systems that are difficult to study by …

The glucose transporter family (GLUT) consists of fourteen members. It is responsible for
glucose homeostasis and glucose transport from the extracellular space to the cell …

Objective Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate
(CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and …

Glucose transport is a highly regulated process and is dependent on a variety of signaling
events. Glycogen synthase kinase-3 (GSK-3) has been implicated in various aspects of the …

The fine-tuning of glucose uptake mechanisms is rendered by various glucose transporters
with distinct transport characteristics. In the pancreatic islet, facilitative diffusion glucose …

Monosaccharides enter cells by slow translipid bilayer diffusion by rapid, protein-mediated,
cation-dependent cotransport and by rapid, protein-mediated equilibrative transport. This …

Primary hepatocellular carcinoma (HCC) is one of the most fatal cancers in humans with
rising incidence in many regions around the world. Currently, no satisfactory curative …

The major facilitator superfamily (MFS) is the largest collection of structurally related
membrane proteins that transport a wide array of substrates. The proton-coupled sugar …