Genetic, biochemical, and cellular studies have uncovered many of the molecular
mechanisms underlying the signaling and repair of chromosomal DNA breaks. However …

The cellular response to DNA damage (DDR) that causes replication collapse and/or DNA
double strand breaks, is characterised by a massive change in the post-translational …

H2AX safeguards genomic stability in a dose-dependent manner; however, mechanisms
governing its proteostasis are poorly understood. Here, we identify a PRMT5-RNF168 …

DNA double-strand breaks (DSBs) are DNA lesions that must be accurately repaired in
order to preserve genomic integrity and cellular viability. The response to DSBs reshapes …

Primary microcephalies (PMs) are defects in brain growth that are detectable at or before
birth and are responsible for neurodevelopmental disorders. Most are caused by biallelic or …

Tyr142, the C-terminal amino acid of histone variant H2A. X is phosphorylated by WSTF
(Williams-Beuren syndrome transcription factor), a component of the WICH complex (WSTF …

Rad18 interacts with the SMC5/6 localization factor 1 (SLF1) to recruit the SMC5/6 complex
to DNA damage sites for repair. The mechanism of the specific Rad18 recognition by SLF1 …

DNA damage that obstructs the replication machinery poses a significant threat to genome
stability. Replication-coupled repair mechanisms safeguard stalled replication forks by …

Phosphorylation-dependent protein–protein interaction has rarely been targeted in
medicinal chemistry. Thymoquinone, a naturally occurring antitumor agent, disrupts …

Chemotherapy remains the most prescribed anti-cancer therapy, despite patients suffering
severe side effects and frequently developing chemoresistance. These complications can be …