A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites,
also known as natural products. Natural products have been a prolific source and an …

Actinomycetes are excellent sources for novel bioactive compounds, which serve as
potential drug candidates for antibiotics development. While industrial efforts to find and …

Actinomycetes are one of the most valuable sources of natural products with industrial and
medicinal importance. After more than half a century of exploitation, it has become …

Secondary metabolites are a reliable and very important source of medicinal compounds.
While these molecules have been mined extensively, genome sequencing has suggested …

Streptomyces is a diverse group of gram-positive microorganisms characterised by a
complex developmental cycle. Streptomycetes produce a number of antibiotics and other …

We describe a procedure for the conjugative transfer of phage P 1-derived A rtificial C
hromosome (PAC) library clones containing large natural product gene clusters (≥ 70 …

The anticoccidial salinomycin is a polyketide produced by Streptomyces albus and requires
malonyl-CoAs, methylmalonyl-CoAs, and ethylmalonyl-CoAs for the backbone assembly …

Rapamycin and its analogs are clinically important macrolide compounds produced by
Streptomyces hygroscopicus. They exhibit antifungal, immunosuppressive, antitumor …

Background FK506 is an important immunosuppressant, which can be produced by
Streptomyces tsukubaensis. However, the production capacity of the strain is very low …

ABSTRACT FK506, a widely used immunosuppressant, is produced by industrial
fermentation processes using various Streptomyces species. However, the low titer …