Extracellular vesicles as an efficient and versatile system for drug delivery

XTT Dang, JM Kavishka, DX Zhang, M Pirisinu, MTN Le - Cells, 2020 - mdpi.com
Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …

ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells

P Fuentes, M Sesé, PJ Guijarro, M Emperador… - Nature …, 2020 - nature.com
Metastasis, the spread of malignant cells from a primary tumour to distant sites, causes 90%
of cancer-related deaths. The integrin ITGB3 has been previously described to play an …

Alternative biological sources for extracellular vesicles production and purification strategies for process scale-up

S Giancaterino, C Boi - Biotechnology Advances, 2023 - Elsevier
Extracellular vesicles (EVs) are phospholipidic bi-layer enclosed nanoparticles secreted
naturally by all cell types. They are attracting increasing attention in the fields of …

Engineered exosomes for studies in tumor immunology

A Alptekin, M Parvin, HI Chowdhury… - Immunological …, 2022 - Wiley Online Library
Exosomes are a type of extracellular vesicle (EV) with diameters of 30–150 nm secreted by
most of the cells into the extracellular spaces and can alter the microenvironment through …

Identifying extracellular vesicle populations from single cells

JM Nikoloff, MA Saucedo-Espinosa… - Proceedings of the …, 2021 - National Acad Sciences
Extracellular vesicles (EVs) are constantly secreted from both eukaryotic and prokaryotic
cells. EVs, including those referred to as exosomes, may have an impact on cell signaling …

Microvesicles in cancer: Small size, large potential

K Menck, S Sivaloganathan, A Bleckmann… - International journal of …, 2020 - mdpi.com
Extracellular vesicles (EV) are secreted by all cell types in a tumor and its microenvironment
(TME), playing an essential role in intercellular communication and the establishment of a …

Surface protein profiling of milk and serum extracellular vesicles unveils body fluid-specific signatures

A Giovanazzi, MJC van Herwijnen, M Kleinjan… - Scientific Reports, 2023 - nature.com
Cell-derived extracellular vesicles (EVs) are currently in the limelight as potential disease
biomarkers. The promise of EV-based liquid biopsy resides in the identification of specific …

Harnessing extracellular vesicle heterogeneity for diagnostic and therapeutic applications

RP Carney, RR Mizenko, BT Bozkurt, N Lowe… - Nature …, 2024 - nature.com
Extracellular vesicles (EVs) are diverse nanoparticles with large heterogeneity in size and
molecular composition. Although this heterogeneity provides high diagnostic value for liquid …

Emerging technologies for profiling extracellular vesicle heterogeneity

G Huang, G Lin, Y Zhu, W Duan, D Jin - Lab on a Chip, 2020 - pubs.rsc.org
Extracellular vesicles (EVs) are membrane-bound vesicles secreted by most cell types and
exist in virtually all bodily fluids. They carry on a wealth of proteomic and genetic information …

Extracellular vesicles and oncogenic signaling

A Schubert, M Boutros - Molecular oncology, 2021 - Wiley Online Library
In recent years, extracellular vesicles (EVs) emerged as potential diagnostic and prognostic
markers for cancer therapy. While the field of EV research is rapidly developing and their …