The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable
source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by …

Infective diseases have become health threat of a global proportion due to appearance and
spread of microorganisms resistant to majority of therapeutics currently used for their …

Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a
protozoan etiology, high incidence, and prevalence in developing countries. As a result …

Quinoline is one of the most common nitrogen-containing heterocycles owing to its
fascinating pharmacological properties and synthetic value in organic and pharmaceutical …

Leishmaniasis is a parasitic neglected tropical disease caused by various species of
Leishmania parasite. Despite tremendous advancements in the therapeutic sector and drug …

1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …

Alpha-amylase and urease enzyme over expression endorses various complications like
rheumatoid arthritis, urinary tract infection, colon cancer, metabolic disorder, cardiovascular …

Leishmaniasis is a severe disease caused by protozoan parasites of the genus Leishmania
and it is accountable for sizable morbidity and mortality worldwide. So far, no effective …

The CF3 group attached to N-aryl hydrazone could be activated upon treatment with a
suitable base, thus serving as an excellent C1 unit for the assembly of a series of 1, 3, 4 …

Heterocyclic compounds containing the quinoline ring play a significant role in organic
synthesis and therapeutic chemistry. Polyfunctionalized quinolines have attracted the …