In vivo visualization of tumor-associated macrophages re-education by photoacoustic/fluorescence dual-modal imaging with a metal-organic frames-based caspase-1 …

Z Fan, X Jiang, T Sun, F Zeng, G Huang, C Liang… - Journal of Colloid and …, 2024 - Elsevier
Tumor-associated macrophages (TAMs) are vital in the tumor microenvironment,
contributing to immunosuppression and therapy tolerance. Despite their importance, the …

Flow-Induced Shear Stress Primes NLRP3 Inflammasome Activation in Macrophages via Piezo1

A Fish, A Kulkarni - ACS Applied Materials & Interfaces, 2024 - ACS Publications
The NLRP3 inflammasome is a crucial component of the innate immune system, playing a
pivotal role in initiating and regulating the body's inflammatory response to various …

Caspase-1 Responsive Nanoreporter for In Vivo Monitoring of Inflammasome Immunotherapy

D Nandi, J Forster III, A Ramesh… - … applied materials & …, 2023 - ACS Publications
Inflammasomes are multimeric protein signaling complexes that are assembled in innate
immune cells in response to a multitude of pathogen and damage-associated signals. They …