Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …

Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …

Late-stage functionalization of natural products offers an elegant route to create novel
entities in a relevant biological target space. In this context, enzymes capable of …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Chiral cyclopropane rings are key pharmacophores in pharmaceuticals and bioactive
natural products, making libraries of these building blocks a valuable resource for drug …

Darobactins represent a class of ribosomally synthesized and post-translationally modified
peptide (RiPP) antibiotics featuring a rare bicyclic structure. They target the Bam-complex of …

During the last 20 years, focus has shifted from haloperoxidases to flavin‐dependent and
non‐heme‐iron halogenases because of their proven involvement in the biosynthesis of …

Halogenating enzymes are increasingly attracting attention for biocatalytic C− H
functionalization. Despite its importance for synthetic chemistry, selective introduction of …

Alkaloid-derived pharmaceuticals are commonly semisynthesized from plant-extracted
starting materials, which often limits their availability and final price. Recent advances in …