Podocytopathies are kidney diseases in which direct or indirect podocyte injury drives
proteinuria or nephrotic syndrome. In children and young adults, genetic variants in> 50 …

The emergence of digital pathology—an image-based environment for the acquisition,
management and interpretation of pathology information supported by computational …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

Background Failure of the glomerular filtration barrier, primarily by loss of slit diaphragm
architecture, underlies nephrotic syndrome in minimal change disease. The etiology …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a
Controversies Conference on glomerular diseases in November 2017. The conference …

Metformin, the most widely prescribed medication for obesity-associated type 2 diabetes
(T2D), lowers plasma glucose levels, food intake, and body weight in rodents and humans …

Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we
report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 …

Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …

Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing
etiologies with monogenic disease accounting for 2.9–30% in selected series. Using whole …