Müller cells are active players in normal retinal function and in virtually all forms of retinal
injury and disease. Reactive Müller cells protect the tissue from further damage and …

The discovery that expansion of unstable repeats can cause a variety of neurological
disorders has changed the landscape of disease-oriented research for several forms of …

Background The persistence in adult teleost fish of retinal stem cells that exhibit all of the
features of true'adult stem cells'–self-renewal, multipotency, and the capacity to respond to …

The generation of neurons and glia in the developing nervous system is likely to be
regulated by extrinsic factors, including growth factors and neurotransmitters. Evidence from …

The diversity inherent in biological systems has its roots in genetic variation but is revealed
through distinctions in the molecular profile and thus the identity of individual cells. The …

A fundamental issue concerning development of the vertebrate retina is the relative
contributions of extrinsic and intrinsic cues to the determination of cell fate. Recent findings …

The fate of cortical progenitors, which progressively generate neurons and glial cells during
development, is determined by temporally and spatially regulated signaling mechanisms …

Prolonged or high-intensity exposure to visible light leads to photoreceptor cell death. In this
study, we demonstrate a novel pathway of light-induced photoreceptor apoptosis involving …

▪ Abstract The nervous system of higher organisms exhibits extraordinary cellular diversity
owing to complex spatial and temporal patterning mechanisms. The role of spatial patterning …

The seven major classes of cells of the vertebrate neural retina are generated from a pool of
multipotent progenitor cells. Recent studies suggest a model of retinal development in which …