Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …

Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are
emerging as an essential antitumor component based on their ability to foster T cell …

We analyze the transcriptome of baseline and on-therapy tumor biopsies from 101 patients
with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with …

Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered
evidence indicates that additional intermediate state (s) may exist. Here, to search for such …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Deregulated WNT signaling has been shown to favor malignant transformation, tumor
progression, and resistance to conventional cancer therapy in a variety of preclinical and …

Background While cancer immunotherapies including checkpoint blockade antibodies,
adoptive T cell therapy, and even some vaccines have given rise to major clinical responses …

Lack of tumor infiltration by immune cells is the main mechanism of primary resistance to
programmed cell death protein 1 (PD-1) blockade therapies for cancer. It has been …

Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus
invasive (INV) subpopulations that represent a" go or grow" trade-off; however, how these …

Despite huge efforts made in academic and pharmaceutical worldwide research, current
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …