Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy
X Lei, Y Lei, JK Li, WX Du, RG Li, J Yang, J Li, F Li… - Cancer letters, 2020 - Elsevier
The immune cells within the tumor microenvironment (TME) play important roles in
tumorigenesis. It has been known that these tumor associated immune cells may possess …
tumorigenesis. It has been known that these tumor associated immune cells may possess …
Myeloid-derived suppressor cells as a therapeutic target for cancer
The emergence of immunotherapy has been an astounding breakthrough in cancer
treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have …
treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have …
Single-cell RNA sequencing analysis: a step-by-step overview
Thanks to innovative sample-preparation and sequencing technologies, gene expression in
individual cells can now be measured for thousands of cells in a single experiment. Since its …
individual cells can now be measured for thousands of cells in a single experiment. Since its …
Tumor functional heterogeneity unraveled by scRNA-seq technologies
L González-Silva, L Quevedo, I Varela - Trends in cancer, 2020 - cell.com
Effective cancer treatment has been precluded by the presence of various forms of
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …
intratumoral complexity that drive treatment resistance and metastasis. Recent single-cell …
High-throughput transcriptome profiling in drug and biomarker discovery
The development of new drugs is multidisciplinary and systematic work. High-throughput
techniques based on “-omics” have driven the discovery of biomarkers in diseases and …
techniques based on “-omics” have driven the discovery of biomarkers in diseases and …
Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments
Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …
Droplet-based single cell RNAseq tools: a practical guide
Droplet based scRNA-seq systems such as Drop-seq, inDrop and Chromium 10X have
been the catalyst for the wide adoption of high-throughput scRNA-seq technologies in the …
been the catalyst for the wide adoption of high-throughput scRNA-seq technologies in the …
Improved survival analysis by learning shared genomic information from pan-cancer data
Motivation Recent advances in deep learning have offered solutions to many biomedical
tasks. However, there remains a challenge in applying deep learning to survival analysis …
tasks. However, there remains a challenge in applying deep learning to survival analysis …
Single-Cell Analysis in Immuno-Oncology
MI Christodoulou, A Zaravinos - International Journal of Molecular …, 2023 - mdpi.com
The complexity of the cellular and non-cellular milieu surrounding human tumors plays a
decisive role in the course and outcome of disease. The high variability in the distribution of …
decisive role in the course and outcome of disease. The high variability in the distribution of …
The current landscape of single-cell transcriptomics for cancer immunotherapy
Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have
revolutionized cancer treatment, but further progress is hindered by our limited …
revolutionized cancer treatment, but further progress is hindered by our limited …