The intestinal epithelium has one of the highest rates of cellular turnover in a process that is
tightly regulated. As the transit-amplifying progenitors of the intestinal epithelium generate …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Fermentative organs such as the caecum, the colon, and the rumen have evolved to
produce and absorb energy rich short chain fatty acids (SCFA) from otherwise indigestible …

The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal
contents to the subepithelium. In addition, the epithelium dictates the initial responses of the …

TMEM16A (known as anoctamin 1) Ca 2+-activated chloride channel is overexpressed in
many tumors. TMEM16A overexpression can be caused by gene amplification in many …

The chemosensory capacity of the somatosensory system relies on the appropriate
expression of chemoreceptors, which detect chemical stimuli and transduce sensory …

Summary Anoctamin 1 (Ano1; TMEM16A) and anoctamin 2 (Ano2; TMEM16B) are novel Cl−
channels transiently activated by an increase in intracellular Ca2+. These channels are …

Abstract Transmembrane protein 16A (TMEM16A) forms a plasma membrane-localized
Ca2+-activated Cl-channel. Its gene has been mapped to an area on chromosome 11q13 …

ABSTRACT The Ca2+‐activated Cl‒channel TMEM16A [anoctamin (ANO) 1] is homologous
to yeast Ist2 and has been shown to tether the cortical endoplasmic reticulum (ER) to the …