Currently> 50 proteins have been reported to be associated with focal contacts and related
ECM adhesions. Most of these contain multiple domains through which they can interact …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

Focal adhesions (FAs) regulate cell migration. Vinculin, with its many potential binding
partners, can interconnect signals in FAs. Despite the well-characterized structure of …

Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for
both cell–cell and cell–extracellular matrix (focal adhesion) adherens-type junctions, but its …

Vinculin, discovered in 1979 (Geiger, 1979), is an adapter protein with binding sites for more
than 15 proteins. Biochemical and structural analyses have contributed to detailed …

Cellular contacts with the extracellular matrix are regulated by the Rho family of GTPases
through their effects on both the actin and the microtubule cytoarchitecture. Recent genetic …

Abstract α-catenin has often been considered to be a non-regulatory intercellular adhesion
protein, in contrast to β-catenin, which has well-documented dual roles in cell–cell adhesion …

Cells integrate biochemical and mechanical information to function within multicellular
tissue. Within developing and remodeling tissues, mechanical forces contain instructive …

Vinculin plays a fundamental role in integrin-mediated cell adhesion. Activated by talin, it
interacts with diverse adhesome components, enabling mechanical coupling between the …

In epithelial cells, α-, β-, and γ-catenin are involved in linking the peripheral microfilament
belt to the transmembrane protein E-cadherin. α-Catenin exhibits sequence homologies …