Candida auris Genetics and Emergence

A Chowdhary, K Jain, N Chauhan - Annual Review of …, 2023 - annualreviews.org
Candida auris is a multidrug-resistant fungal pathogen that presents a serious threat to
global human health. Since the first reported case in 2009 in Japan, C. auris infections have …

Multidrug resistance in mammals and fungi—from MDR to PDR: a rocky road from atomic structures to transport mechanisms

N Khunweeraphong, K Kuchler - International journal of molecular …, 2021 - mdpi.com
Multidrug resistance (MDR) can be a serious complication for the treatment of cancer as well
as for microbial and parasitic infections. Dysregulated overexpression of several members of …

Directed evolution detects supernumerary centric chromosomes conferring resistance to azoles in Candida auris

A Narayanan, P Kumar, A Chauhan, M Kumar, K Yadav… - MBio, 2022 - Am Soc Microbiol
Candida auris exhibits resistance to multiple antifungal drug classes and sterilization
agents, posing threats to the immunocompromised worldwide. Among the four major …

[HTML][HTML] Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance

AA Rabaan, K Eljaaly, WA Alfouzan, A Al Mutair… - Journal of Infection and …, 2023 - Elsevier
In recent years, we are facing the challenge of drug resistance emergence in fungi. The
availability of limited antifungals and development of multi-drug resistance in fungal …

[HTML][HTML] Native human and mouse skin infection models to study Candida auris-host interactions

S Seiser, H Arzani, T Ayub, T Phan-Canh, C Staud… - Microbes and …, 2024 - Elsevier
Abstract The World Health Organization (WHO) declared certain fungal pathogens as global
health threats for the next decade. Candida auris (C. auris) is a newly emerging skin-tropic …

Bibliometric analysis and thematic review of Candida pathogenesis: Fundamental omics to applications as potential antifungal drugs and vaccines

SJ Lim, ND Muhd Noor, S Sabri… - Medical …, 2024 - academic.oup.com
Invasive candidiasis caused by the pathogenic Candida yeast species has resulted in
elevating global mortality. The pathogenicity of Candida spp. is not only originated from its …

Phenotypic and genetic features of a novel clinically isolated rough morphotype Candida auris

S Tian, J Bing, Y Chu, H Li, Q Wang, S Cheng… - Frontiers in …, 2023 - frontiersin.org
Introduction Candida auris is a newly emerging pathogenic fungus of global concern and
has been defined by the World Health Organization (WHO) as a member of the critical group …

Transcriptomics and phenotyping define genetic signatures associated with echinocandin resistance in Candida auris

S Jenull, R Shivarathri, I Tsymala, P Penninger… - Mbio, 2022 - Am Soc Microbiol
Candida auris emerged as a human fungal pathogen only during the past decade.
Remarkably, C. auris displays high degrees of genomic diversity and phenotypic plasticity …

Sphingolipid diversity in Candida auris: unraveling interclade and drug resistance fingerprints

B Ali, M Kumar, P Kumar, A Chauhan… - FEMS Yeast …, 2024 - academic.oup.com
In this study, we explored the sphingolipid (SL) landscape in Candida auris, which plays
pivotal roles in fungal biology and drug susceptibility. The composition of SLs exhibited …

Impact of the acquired subgenome on the transcriptional landscape in Brettanomyces bruxellensis allopolyploids

A Jallet, A Friedrich, J Schacherer - G3: Genes, Genomes …, 2023 - academic.oup.com
Gene expression variation can provide an overview of the changes in regulatory networks
that underlie phenotypic diversity. Certain evolutionary trajectories such as polyploidization …