Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

Abstract RNA polymerase II (RNA Pol II) speed or elongation rate, ie, the number of
nucleotides synthesized per unit of time, is a major determinant of transcriptome …

How transcription affects genome 3D organization is not well understood. We found that
during influenza A (IAV) infection, rampant transcription rapidly reorganizes host cell …

Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

Many eukaryotic genes generate linear mRNAs and circular RNAs, but it is largely unknown
how the ratio of linear to circular RNA is controlled or modulated. Using RNAi screening in …

Single-cell RNA genomics technologies are revolutionizing biomedical science by profiling
single cells with unprecedented resolution, providing fundamental insights into the role of …

RNA Polymerase II (Pol II) and transcription factors form concentrated hubs in cells via
multivalent protein-protein interactions, often mediated by proteins with intrinsically …

BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …

mRNA translation decodes nucleotide into amino acid sequences. However, translation has
also been shown to affect mRNA stability depending on codon composition in model …

Characterizing complex viral transcriptomes by conventional RNA sequencing approaches
is complicated by high gene density, overlapping reading frames, and complex splicing …