Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
Application of computational approaches in biomembranes: From structure to function
J Guo, Y Bao, M Li, S Li, L Xi, P Xin… - Wiley …, 2023 - Wiley Online Library
Biological membranes (biomembranes) are one of the most complicated structures that
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …
[HTML][HTML] Structural determinants and functional consequences of protein affinity for membrane rafts
Eukaryotic plasma membranes are compartmentalized into functional lateral domains,
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …
[HTML][HTML] Protein partitioning into ordered membrane domains: insights from simulations
Cellular membranes are laterally organized into domains of distinct structures and
compositions by the differential interaction affinities between various membrane lipids and …
compositions by the differential interaction affinities between various membrane lipids and …
Lipid Acyl Chain cis Double Bond Position Modulates Membrane Domain Registration/Anti-Registration
S Zhang, X Lin - Journal of the American Chemical Society, 2019 - ACS Publications
Inter-leaflet coupling is critical to control the dynamics of membrane domain registration/anti-
registration, which is important in maintaining proper biological functions. Factors such as …
registration, which is important in maintaining proper biological functions. Factors such as …
RAS GTPases and Interleaflet Coupling in the Plasma Membrane
RAS genes are frequently mutated in cancer. The primary signaling compartment of wild-
type and constitutively active oncogenic mutant RAS proteins is the inner leaflet of the …
type and constitutively active oncogenic mutant RAS proteins is the inner leaflet of the …
Cholesterol flip-flop impacts domain registration in plasma membrane models
S Thallmair, HI Ingólfsson… - The journal of physical …, 2018 - ACS Publications
The plasma membrane is a highly complex multicomponent system that is central to the
functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes …
functioning of cells. Cholesterol, a key lipid component of the plasma membrane, promotes …
Domain stability in biomimetic membranes driven by lipid polyunsaturation
Biological membranes contain a broad variety of lipid species whose individual
physicochemical properties and collective interactions ultimately determine membrane …
physicochemical properties and collective interactions ultimately determine membrane …
The fine‐tuning of cell membrane lipid bilayers accentuates their compositional complexity
T Dingjan, AH Futerman - BioEssays, 2021 - Wiley Online Library
Cell membranes are now emerging as finely tuned molecular systems, signifying that re‐
evaluation of our understanding of their structure is essential. Although the idea that cell …
evaluation of our understanding of their structure is essential. Although the idea that cell …
Optimization of hydrophobic nanoparticles to better target lipid rafts with molecular dynamics simulations
Due to different interactions between lipids and proteins, a plasma membrane can
segregate into different membrane domains. Among them, ordered functional membrane …
segregate into different membrane domains. Among them, ordered functional membrane …