Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo
EA Ashworth, RCT Wright, RK Shears… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease
including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health …
including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health …
Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor
JP Cerna-Vargas, VM Gumerov… - Proceedings of the …, 2023 - National Acad Sciences
Bacteria possess various receptors that sense different signals and transmit information to
enable an optimal adaptation to the environment. A major limitation in microbiology is the …
enable an optimal adaptation to the environment. A major limitation in microbiology is the …
Icescape‐scale metabolomics reveals cyanobacterial and topographic control of the core metabolism of the cryoconite ecosystem of an Arctic ice cap
Glaciers host ecosystems comprised of biodiverse and active microbiota. Among glacial
ecosystems, less is known about the ecology of ice caps since most studies focus on valley …
ecosystems, less is known about the ecology of ice caps since most studies focus on valley …
Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
A Andriianov, S Trigüis, A Drobiazko, N Sierro… - Cell Reports, 2023 - cell.com
Bacteriophage T3 encodes a SAMase that, through cleavage of S-adenosyl methionine
(SAM), circumvents the SAM-dependent type I restriction-modification (RM) defense. We …
(SAM), circumvents the SAM-dependent type I restriction-modification (RM) defense. We …
Discovering unknown associations between prokaryotic receptors and their ligands
M Dlakić - Proceedings of the National Academy of …, 2023 - National Acad Sciences
The motility of microorganisms through the environment is driven by chemical gradients:
They move towards nutrients and away from signals that indicate unfavorable conditions …
They move towards nutrients and away from signals that indicate unfavorable conditions …
Cell-lysis sensing drives biofilm formation in Vibrio cholerae
JA Prentice, R van de Weerd, AA Bridges - Nature Communications, 2024 - nature.com
Matrix-encapsulated communities of bacteria, called biofilms, are ubiquitous in the
environment and are notoriously difficult to eliminate in clinical and industrial settings …
environment and are notoriously difficult to eliminate in clinical and industrial settings …
[HTML][HTML] Identification and targeting of microbial putrescine acetylation in bloodstream infections
JR Mayers, J Varon, RR Zhou, M Daniel-Ivad… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The growth of antimicrobial resistance (AMR) has highlighted an urgent need to identify
bacterial pathogenic functions that may be targets for clinical intervention. Although severe …
bacterial pathogenic functions that may be targets for clinical intervention. Although severe …
The uncharacterized PA3040-3042 operon is part of the cell envelope stress response and a tobramycin resistance determinant in a clinical isolate of Pseudomonas …
MZ Østergaard, FD Nielsen, MH Meinfeldt… - Microbiology …, 2024 - journals.asm.org
ABSTRACT Bacteriophages (hereafter “phages”) are ubiquitous predators of bacteria in the
natural world, but interest is growing in their development into antibacterial therapy as …
natural world, but interest is growing in their development into antibacterial therapy as …
Fight not flight: parasites drive the bacterial evolution of resistance, not escape
M Blazanin, J Moore, S Olsen, M Travisano - bioRxiv, 2023 - biorxiv.org
In the face of ubiquitous threats from parasites, hosts can evolve strategies to resist infection
or to altogether avoid parasitism, for instance by avoiding behavior that could expose them …
or to altogether avoid parasitism, for instance by avoiding behavior that could expose them …
Delving into “Dark Matter” and an Anti-Phage Defense Encoded by Pseudomonas aeruginosa Phage LES4
A DasGupta - 2023 - search.proquest.com
The evolutionary arms race between bacteria and phages has given rise to myriad bacterial
anti-phage defenses and phage-encoded counters to those defenses. Phages themselves …
anti-phage defenses and phage-encoded counters to those defenses. Phages themselves …