Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo

EA Ashworth, RCT Wright, RK Shears… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease
including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health …

Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor

JP Cerna-Vargas, VM Gumerov… - Proceedings of the …, 2023 - National Acad Sciences
Bacteria possess various receptors that sense different signals and transmit information to
enable an optimal adaptation to the environment. A major limitation in microbiology is the …

Icescape‐scale metabolomics reveals cyanobacterial and topographic control of the core metabolism of the cryoconite ecosystem of an Arctic ice cap

JK Gokul, LAJ Mur, AJ Hodson… - Environmental …, 2023 - Wiley Online Library
Glaciers host ecosystems comprised of biodiverse and active microbiota. Among glacial
ecosystems, less is known about the ecology of ice caps since most studies focus on valley …

Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase

A Andriianov, S Trigüis, A Drobiazko, N Sierro… - Cell Reports, 2023 - cell.com
Bacteriophage T3 encodes a SAMase that, through cleavage of S-adenosyl methionine
(SAM), circumvents the SAM-dependent type I restriction-modification (RM) defense. We …

Discovering unknown associations between prokaryotic receptors and their ligands

M Dlakić - Proceedings of the National Academy of …, 2023 - National Acad Sciences
The motility of microorganisms through the environment is driven by chemical gradients:
They move towards nutrients and away from signals that indicate unfavorable conditions …

Cell-lysis sensing drives biofilm formation in Vibrio cholerae

JA Prentice, R van de Weerd, AA Bridges - Nature Communications, 2024 - nature.com
Matrix-encapsulated communities of bacteria, called biofilms, are ubiquitous in the
environment and are notoriously difficult to eliminate in clinical and industrial settings …

[HTML][HTML] Identification and targeting of microbial putrescine acetylation in bloodstream infections

JR Mayers, J Varon, RR Zhou, M Daniel-Ivad… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The growth of antimicrobial resistance (AMR) has highlighted an urgent need to identify
bacterial pathogenic functions that may be targets for clinical intervention. Although severe …

The uncharacterized PA3040-3042 operon is part of the cell envelope stress response and a tobramycin resistance determinant in a clinical isolate of Pseudomonas …

MZ Østergaard, FD Nielsen, MH Meinfeldt… - Microbiology …, 2024 - journals.asm.org
ABSTRACT Bacteriophages (hereafter “phages”) are ubiquitous predators of bacteria in the
natural world, but interest is growing in their development into antibacterial therapy as …

Fight not flight: parasites drive the bacterial evolution of resistance, not escape

M Blazanin, J Moore, S Olsen, M Travisano - bioRxiv, 2023 - biorxiv.org
In the face of ubiquitous threats from parasites, hosts can evolve strategies to resist infection
or to altogether avoid parasitism, for instance by avoiding behavior that could expose them …

Delving into “Dark Matter” and an Anti-Phage Defense Encoded by Pseudomonas aeruginosa Phage LES4

A DasGupta - 2023 - search.proquest.com
The evolutionary arms race between bacteria and phages has given rise to myriad bacterial
anti-phage defenses and phage-encoded counters to those defenses. Phages themselves …