Ion mobility mass spectrometry for the separation and characterization of small molecules
Small molecules with molecular weights less than 1500 Da represented by natural
metabolites such as amino acids, nucleotides, carbohydrates, lipids, flavonoids, alkaloids …
metabolites such as amino acids, nucleotides, carbohydrates, lipids, flavonoids, alkaloids …
[HTML][HTML] Collision cross section prediction based on machine learning
X Li, H Wang, M Jiang, M Ding, X Xu, B Xu, Y Zou, Y Yu… - Molecules, 2023 - mdpi.com
Ion mobility-mass spectrometry (IM-MS) is a powerful separation technique providing an
additional dimension of separation to support the enhanced separation and characterization …
additional dimension of separation to support the enhanced separation and characterization …
Structural characterization and quantitation of ether-Linked glycerophospholipids in peroxisome biogenesis disorder tissue by ultraviolet photodissociation mass …
MS Blevins, SWJ Shields, W Cui, W Fallatah… - Analytical …, 2022 - ACS Publications
The biological impact of ether glycerophospholipids (GP) in peroxisomal disorders and other
diseases makes them significant targets as biomarkers for diagnostic assays or deciphering …
diseases makes them significant targets as biomarkers for diagnostic assays or deciphering …
[HTML][HTML] Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers
SM Camunas-Alberca, M Moran-Garrido… - Frontiers in Molecular …, 2023 - frontiersin.org
It is increasingly evident that a more detailed molecular structure analysis of isomeric lipids
is critical to better understand their roles in biological processes. The occurrence of isomeric …
is critical to better understand their roles in biological processes. The occurrence of isomeric …
Nanohydrophobic interaction chromatography coupled to ultraviolet photodissociation mass spectrometry for the analysis of intact proteins in low charge states
The direct correlation between proteoforms and biological phenotype necessitates the
exploration of mass spectrometry (MS)-based methods more suitable for proteoform …
exploration of mass spectrometry (MS)-based methods more suitable for proteoform …
Separation and collision cross section measurements of protein complexes afforded by a modular drift tube coupled to an orbitrap mass spectrometer
New developments in analytical technologies and biophysical methods have advanced the
characterization of increasingly complex biomolecular assemblies using native mass …
characterization of increasingly complex biomolecular assemblies using native mass …
A non-FRET DNA reporter that changes fluorescence colour upon nuclease digestion
Fluorescence resonance energy transfer (FRET) reporters are commonly used in the final
stages of nucleic acid amplification tests to indicate the presence of nucleic acid targets …
stages of nucleic acid amplification tests to indicate the presence of nucleic acid targets …
Improving Ion Mobility Mass Spectrometry of Proteins through Tristate Gating and Optimization of Multiplexing Parameters
Coupling drift tube ion mobility (IM) to Fourier transform mass spectrometry (FT-MS) affords
the opportunity for gas-phase separation of ions based on size and conformation with high …
the opportunity for gas-phase separation of ions based on size and conformation with high …
Recent Analytical Methodologies in Lipid Analysis
I Gerhardtova, T Jankech, P Majerova… - International Journal of …, 2024 - mdpi.com
Lipids represent a large group of biomolecules that are responsible for various functions in
organisms. Diseases such as diabetes, chronic inflammation, neurological disorders, or …
organisms. Diseases such as diabetes, chronic inflammation, neurological disorders, or …
Expanding Orbitrap Collision Cross-Section Measurements to Native Protein Applications Through Kinetic Energy and Signal Decay Analysis
The measurement of collision cross sections (CCS, σ) offers supplemental information about
sizes and conformations of ions beyond mass analysis alone. We have previously shown …
sizes and conformations of ions beyond mass analysis alone. We have previously shown …