Pavlovian fear conditioning is a particularly useful behavioral paradigm for exploring the
molecular mechanisms of learning and memory because a well-defined response to a …

Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

The last 10 years have witnessed a surge of interest for the mechanisms underlying the
acquisition and extinction of classically conditioned fear responses. In part, this results from …

Considerable progress has been made over the past 20 years in relating specific circuits of
the brain to emotional functions. Much of this work has involved studies of Pavlovian or …

Many of the diverse functional consequences of activating group 1 metabotropic glutamate
receptors require translation of pre-existing mRNA near synapses. One of these …

The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

Fear is an adaptive component of the acute “stress” response to potentially-dangerous
(external and internal) stimuli which threaten to perturb homeostasis. However, when …

Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and
current treatments are less than satisfactory. So, the discovery of novel approaches to treat …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Fear conditioning is a valuable behavioral paradigm for studying the neural basis of
emotional learning and memory. The lateral nucleus of the amygdala (LA) is a crucial site of …