The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Biological clocks are genetically encoded oscillators that allow organisms to anticipate
changes in the light–dark environment that are tied to the rotation of Earth. Clocks enhance …

Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …

Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular
health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV …

The circadian clock programs daily rhythms and coordinates multiple behavioral and
physiological processes, including activity, sleep, feeding, and fuel homeostasis. Recent …

T-helper cells that produce interleukin-17 (TH17 cells) are a recently identified CD4+ T-cell
subset with characterized pathological roles in autoimmune diseases,,. The nuclear …

The incidence of the metabolic syndrome represents a spectrum of disorders that continue to
increase across the industrialized world. Both genetic and environmental factors contribute …

All species organize behaviors to optimally match daily changes in the environment, leading
to pronounced activity/rest cycles that track the light/dark cycle. Endogenous, approximately …

Disruption of the circadian rhythm is a contributory factor to clinical and pathophysiological
conditions, including cancer, the metabolic syndrome, and inflammation. Chronic and …

The mammalian circadian clockwork is composed of a core PER/CRY feedback loop and
additional interlocking loops. In particular, the ROR/REV/Bmal1 loop, consisting of ROR …