Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians
G Simitian, M Virumbrales-Muñoz… - Lab on a Chip, 2022 - pubs.rsc.org
Neovascularization, the formation of new blood vessels, has received much research
attention due to its implications for physiological processes and diseases. Most studies …
attention due to its implications for physiological processes and diseases. Most studies …
Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges
SI Montanez-Sauri, DJ Beebe, KE Sung - Cellular and molecular life …, 2015 - Springer
The increasing interest in studying cells using more in vivo-like three-dimensional (3D)
microenvironments has created a need for advanced 3D screening platforms with enhanced …
microenvironments has created a need for advanced 3D screening platforms with enhanced …
Open microfluidic capillary systems
E Berthier, AM Dostie, UN Lee, J Berthier… - Analytical …, 2019 - ACS Publications
Open microfluidic capillary systems are a rapidly evolving branch of microfluidics where
fluids are manipulated by capillary forces in channels lacking physical walls on all sides …
fluids are manipulated by capillary forces in channels lacking physical walls on all sides …
Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier
JD Wang, ES Khafagy, K Khanafer… - Molecular …, 2016 - ACS Publications
The endothelial cells lining the capillaries supplying the brain with oxygen and nutrients
form a formidable barrier known as the blood–brain barrier (BBB), which exhibits selective …
form a formidable barrier known as the blood–brain barrier (BBB), which exhibits selective …
Enabling perfusion through multicellular tumor spheroids promoting lumenization in a vascularized cancer model
A tumor is composed of heterogeneous cell population, which is known as tumor stroma. In
particular, blood vessels have an indispensable role in the tumor microenvironment acting …
particular, blood vessels have an indispensable role in the tumor microenvironment acting …
An in vitro model of the tumor–lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion
The most common cancers, including breast and skin, disseminate initially through the
lymphatic system, yet the mechanisms by which tumor cells home towards, enter and …
lymphatic system, yet the mechanisms by which tumor cells home towards, enter and …
Integrated in silico and 3D in vitro model of macrophage migration in response to physical and chemical factors in the tumor microenvironment
Macrophages are abundant in the tumor microenvironment (TME), serving as accomplices
to cancer cells for their invasion. Studies have explored the biochemical mechanisms that …
to cancer cells for their invasion. Studies have explored the biochemical mechanisms that …
Tumor spheroids under perfusion within a 3D microfluidic platform reveal critical roles of cell-cell adhesion in tumor invasion
Tumor invasion within the interstitial space is critically regulated by the force balance
between cell-extracellular matrix (ECM) and cell-cell interactions. Interstitial flows (IFs) are …
between cell-extracellular matrix (ECM) and cell-cell interactions. Interstitial flows (IFs) are …
Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model
Mimicking the physiological or pathophysiological barrier function of endothelial and
epithelial cells is an essential consideration in organ-on-a-chip models of numerous tissues …
epithelial cells is an essential consideration in organ-on-a-chip models of numerous tissues …
Interstitial flows promote amoeboid over mesenchymal motility of breast cancer cells revealed by a three dimensional microfluidic model
Malignant tumors are often associated with an elevated fluid pressure due to the abnormal
growth of vascular vessels, and thus an increased interstitial flow out of the tumors. Recent …
growth of vascular vessels, and thus an increased interstitial flow out of the tumors. Recent …