Lung cancer is one of the leading causes of cancer death. Non-small-cell lung cancer
(NSCLC) accounts for the majority of lung cancer diagnoses. Dihydrotanshinone (DHT) is a …

The type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic
reticulum that is essential for skeletal muscle contraction. RyR1 forms a channel with six …

Aims Although zinc pyrithione (ZPT) has been studied as topical antimicrobial and cosmetic
consumer products, little is known about its pharmacological actions in gastrointestinal (GI) …

Abstract Ryanodine receptor 2 (RyR2) is a Ca 2+ release channel mainly located on the
sarcoplasmic reticulum (SR) membrane of heart muscle cells and regulates the …

Inherited arrhythmia syndromes (IASs) can cause life-threatening arrhythmias and are
responsible for a significant proportion of sudden cardiac deaths (SCDs). Despite progress …

Background: CaM (calmodulin) is a ubiquitously expressed, multifunctional Ca2+ sensor
protein that regulates numerous proteins. Recently, CaM missense variants have been …

Although glucose, as a secretagogue of intestinal hormone, can stimulate glucagon‐like
peptide 1 (GLP‐1) release, it has not been fully elucidated how glucose triggers GLP‐1 …

Type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic/
sarcoplasmic reticulum (ER/SR) that plays a central role in the excitation-contraction …

Abstract Ryanodine receptor 2 (RyR2) is a large Ca 2+-release channel in the sarcoplasmic
reticulum (SR) of cardiac muscle cells. It serves to release Ca 2+ from the SR into the cytosol …

Background: Excessive activation of the type 2 ryanodine receptor (RyR2) causes lethal
arrhythmias such as catecholaminergic polymorphic ventricular tachycardia (CPVT) …