T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The immune system has tailored its effector functions to optimally respond to distinct species
of microbes. Based on emerging knowledge on the different effector T-cell and innate …

CD4+ T cells are crucial for directing appropriate immune responses during host defense
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …

Allergy is a major public health problem with a high socio‐economic impact. The number of
allergic patients is expected to reach to four billion within two decades when the World's …

Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a
desensitizing therapy for IgE-mediated allergic diseases and represents a potentially …

Numerous cell types are involved in maintenance of the intestinal tissue. However, the main
players are cells of the epithelial lining and the immune system. Human peripheral blood …

The C-type lectin receptor–Syk (spleen tyrosine kinase) adaptor CARD9 facilitates protective
antifungal immunity within the central nervous system (CNS), as human deficiency in …

Chronic rhinosinusitis (CRS) is a complex disease consisting of several disease variants
with different underlying pathophysiologies. Limited knowledge of the mechanisms of these …

The prevalence of allergic diseases has significantly increased in industrialized countries.
Allergen-specific immunotherapy (AIT) remains as the only curative treatment. The …

There have been extensive developments on cellular and molecular mechanisms of
immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ …