A summary of the inaugural WHO classification of pediatric tumors: transitioning from the optical into the molecular era
SM Pfister, M Reyes-Múgica, JKC Chan, H Hasle… - Cancer discovery, 2022 - AACR
Pediatric tumors are uncommon, yet are the leading cause of cancer-related death in
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …
childhood. Tumor types, molecular characteristics, and pathogenesis are unique, often …
The 2021 WHO classification of tumors of the central nervous system: an update on pediatric low‐grade gliomas and glioneuronal tumors
TA Bale, MK Rosenblum - Brain Pathology, 2022 - Wiley Online Library
The 2021 5th edition of the WHO Classification of Tumors of the Central Nervous System
reflects the discovery of genetic alterations underlying many central nervous system (CNS) …
reflects the discovery of genetic alterations underlying many central nervous system (CNS) …
[HTML][HTML] Dabrafenib plus Trametinib in Pediatric Glioma with BRAF V600 Mutations
Background Detection of the BRAF V600E mutation in pediatric low-grade glioma has been
associated with a lower response to standard chemotherapy. In previous trials, dabrafenib …
associated with a lower response to standard chemotherapy. In previous trials, dabrafenib …
The landscape of genomic alterations across childhood cancers
SN Gröbner, BC Worst, J Weischenfeldt, I Buchhalter… - Nature, 2018 - nature.com
Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …
Integrated molecular and clinical analysis of 1,000 pediatric low-grade gliomas
Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre …
J Fangusaro, A Onar-Thomas, TY Poussaint… - The lancet …, 2019 - thelancet.com
Background Paediatric low-grade glioma is the most common CNS tumour of childhood.
Although overall survival is good, disease often recurs. No single universally accepted …
Although overall survival is good, disease often recurs. No single universally accepted …
Uncovering novel mutational signatures by de novo extraction with SigProfilerExtractor
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …
Pediatric low-grade glioma in the era of molecular diagnostics
Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …
spectrum of histologic entities which are currently assigned World Health Organisation …
The 2016 World Health Organization classification of tumors of the central nervous system: a summary
Abstract The 2016 World Health Organization Classification of Tumors of the Central
Nervous System is both a conceptual and practical advance over its 2007 predecessor. For …
Nervous System is both a conceptual and practical advance over its 2007 predecessor. For …
Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas
Cancer Genome Atlas Research … - New England Journal of …, 2015 - Mass Medical Soc
Background Diffuse low-grade and intermediate-grade gliomas (which together make up the
lower-grade gliomas, World Health Organization grades II and III) have highly variable …
lower-grade gliomas, World Health Organization grades II and III) have highly variable …