Nanozymes for regenerative medicine

X Mou, Q Wu, Z Zhang, Y Liu, J Zhang, C Zhang… - Small …, 2022 - Wiley Online Library
Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under
relevant physiological conditions following enzyme kinetics. Compared to natural enzymes …

Crosstalk between the oxidative stress and glia cells after stroke: from mechanism to therapies

G Zhu, X Wang, L Chen, C Lenahan, Z Fu… - Frontiers in …, 2022 - frontiersin.org
Stroke is the second leading cause of global death and is characterized by high rates of
mortality and disability. Oxidative stress is accompanied by other pathological processes …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

[HTML][HTML] A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of …

C Wu, M Du, R Yu, Y Cheng, B Wu, J Fu, W Tan… - Free Radical Biology …, 2022 - Elsevier
Traumatic brain injury (TBI) can lead to disability or devastating consequences with few
established treatments. Although ferroptosis has been shown to be involved in TBI, the …

Oxidative Stress‐Mediated Blood‐Brain Barrier (BBB) Disruption in Neurological Diseases

K Song, Y Li, H Zhang, N An, Y Wei… - Oxidative medicine …, 2020 - Wiley Online Library
The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Neuroprotection against oxidative stress: Phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system

MA Hannan, R Dash, AAM Sohag… - Frontiers in Molecular …, 2020 - frontiersin.org
Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related
disorders, including neurodegenerative diseases and ischemic stroke, which are the major …

Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Microplastics induce neurotoxicity in aquatic animals at environmentally realistic concentrations: A meta-analysis

F Xiong, J Liu, K Xu, J Huang, D Wang, F Li… - Environmental …, 2023 - Elsevier
Microplastics (MPs) draw international attention owing to their widespread distribution in
water ecosystems, but whether MPs cause neurotoxic effects in aquatic animals at …

Amplified gliosis and interferon-associated inflammation in the aging brain following diffuse traumatic brain injury

LM Wangler, CE Bray, JM Packer, ZM Tapp… - Journal of …, 2022 - Soc Neuroscience
Traumatic brain injury (TBI) is associated with chronic psychiatric complications and
increased risk for development of neurodegenerative pathology. Aged individuals account …

Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …