Roles and mechanisms of exosomal non-coding RNAs in human health and diseases
C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …
Mito‐bomb: targeting mitochondria for cancer therapy
X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …
Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation
C Schiliro, BL Firestein - Cells, 2021 - mdpi.com
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …
and proliferation. These metabolic alterations include (1) a shift from oxidative …
Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
underlying stress adaptation of cancer cells in response to therapy-induced hostile …
Tumor Selective Metabolic Reprogramming as a Prospective PD‐L1 Depression Strategy to Reactivate Immunotherapy
Currently, the role of the lysosome, endoplasmic reticulum, or dictyosome in the transcription
and translation of programmed cell death ligand 1 (PD‐L1) is well revealed, but the role and …
and translation of programmed cell death ligand 1 (PD‐L1) is well revealed, but the role and …
ROS production by mitochondria: function or dysfunction?
In eukaryotic cells, ATP generation is generally viewed as the primary function of
mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are …
mitochondria under normoxic conditions. Reactive oxygen species (ROS), in contrast, are …
Metabolic Intervention Liposome Boosted Lung Cancer Radio‐Immunotherapy via Hypoxia Amelioration and PD‐L1 Restraint
S Wang, Z Zhou, R Hu, M Dong, X Zhou… - Advanced …, 2023 - Wiley Online Library
At present, radiotherapy (RT) still acquires limited success in clinical due to the lessened
DNA damage under hypoxia and acquired immune tolerance owing to the amplified …
DNA damage under hypoxia and acquired immune tolerance owing to the amplified …
GSH-responsive nanoprodrug to inhibit glycolysis and alleviate immunosuppression for cancer therapy
X Liu, Y Li, K Wang, Y Chen, M Shi, X Zhang… - Nano Letters, 2021 - ACS Publications
Blocking energy metabolism of cancer cells and simultaneously stimulating the immune
system to perform immune attack are significant for cancer treatment. However, how to …
system to perform immune attack are significant for cancer treatment. However, how to …
Metabolic rewiring in the promotion of cancer metastasis: mechanisms and therapeutic implications
Tumor metastasis is the major cause of mortality from cancer. Metabolic rewiring and the
metastatic cascade are highly intertwined, co-operating to promote multiple steps of cancer …
metastatic cascade are highly intertwined, co-operating to promote multiple steps of cancer …
A vanadium-based nanoplatform synergizing ferroptotic-like therapy with glucose metabolism intervention for enhanced cancer cell death and antitumor immunity
Y Zhang, X Du, Z He, S Gao, L Ye, J Ji, X Yang… - ACS nano, 2023 - ACS Publications
Ferroptosis activation has been considered a mighty weapon for cancer treatment, and
growing attention is being paid to reinforcing tumor cells' sensitivity to ferroptosis. However …
growing attention is being paid to reinforcing tumor cells' sensitivity to ferroptosis. However …