Bufalin is an endogenous cardiotonic steroid, first discovered in toad venom but also found
in the plasma of healthy humans, with anti-tumour activities in different cancer types. The …

Toad venom, a traditional natural medicine, has been used for hundreds of years in China
for treating different diseases. Many studies have been performed to elucidate the …

Autophagy, a double-edged sword for cell survival, is the research object on 2016 Nobel
Prize in Physiology or Medicine. Autophagy is a molecular mechanism for maintaining …

Aim of the review In the past decade, increasing research attention investigated the novel
therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its …

Curcumin is a polyphenolic compound which possesses anticancer potential. It has been
shown to induce cell death in a variety of cancer cells, however, its effect on CAL27‑cisplatin …

Kaempferol belongs to the flavonoid family and has been used in traditional folk medicine.
Here, we investigated the antitumor effects of kaempferol on cell cycle arrest and autophagic …

Abstract Syndecan-4 (SDC4) functions as a major endogenous membrane-associated
receptor and widely regulates cytoskeleton, cell adhesion, and cell migration in human …

BACKGROUND: Autophagy plays distinct roles in apoptosis and the inflammatory process.
Understanding the role of autophagy in sepsis-induced acute lung injury (ALI) may provide …

The traditional Chinese medicine bufalin, extracted from toad's skin, has been demonstrated
to exert anticancer activities in various kinds of human cancers. The mechanisms of action …

Background/purpose Cisplatin-resistant oral cancer is clinically difficult to manage and the
dose-dependent toxicities of cisplatin has been widely concerned. Allyl isothiocyanate …