Bufalin for an innovative therapeutic approach against cancer
L Soumoy, GE Ghanem, S Saussez, F Journe - Pharmacological Research, 2022 - Elsevier
Bufalin is an endogenous cardiotonic steroid, first discovered in toad venom but also found
in the plasma of healthy humans, with anti-tumour activities in different cancer types. The …
in the plasma of healthy humans, with anti-tumour activities in different cancer types. The …
Toad venom: A comprehensive review of chemical constituents, anticancer activities, and mechanisms
FJ Li, JH Hu, X Ren, CM Zhou, Q Liu… - Archiv der …, 2021 - Wiley Online Library
Toad venom, a traditional natural medicine, has been used for hundreds of years in China
for treating different diseases. Many studies have been performed to elucidate the …
for treating different diseases. Many studies have been performed to elucidate the …
[HTML][HTML] Autophagy and its link to type II diabetes mellitus
Autophagy, a double-edged sword for cell survival, is the research object on 2016 Nobel
Prize in Physiology or Medicine. Autophagy is a molecular mechanism for maintaining …
Prize in Physiology or Medicine. Autophagy is a molecular mechanism for maintaining …
[HTML][HTML] New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin
C Cheng, J Wang, J Chen, KT Kuo, J Tang… - Cancer Cell …, 2019 - Springer
Aim of the review In the past decade, increasing research attention investigated the novel
therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its …
therapeutic potential of steroidal cardiac glycosides in cancer treatment. Huachansu and its …
[HTML][HTML] Curcumin-loaded nanoparticles induce apoptotic cell death through regulation of the function of MDR1 and reactive oxygen species in cisplatin-resistant CAR …
Curcumin is a polyphenolic compound which possesses anticancer potential. It has been
shown to induce cell death in a variety of cancer cells, however, its effect on CAL27‑cisplatin …
shown to induce cell death in a variety of cancer cells, however, its effect on CAL27‑cisplatin …
[HTML][HTML] Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 …
Kaempferol belongs to the flavonoid family and has been used in traditional folk medicine.
Here, we investigated the antitumor effects of kaempferol on cell cycle arrest and autophagic …
Here, we investigated the antitumor effects of kaempferol on cell cycle arrest and autophagic …
[HTML][HTML] Therapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma
H Yang, Y Liu, MM Zhao, Q Guo, XK Zheng, D Liu… - Cell Death & …, 2021 - nature.com
Abstract Syndecan-4 (SDC4) functions as a major endogenous membrane-associated
receptor and widely regulates cytoskeleton, cell adhesion, and cell migration in human …
receptor and widely regulates cytoskeleton, cell adhesion, and cell migration in human …
Enhancing autophagy with activated protein C and rapamycin protects against sepsis-induced acute lung injury
BACKGROUND: Autophagy plays distinct roles in apoptosis and the inflammatory process.
Understanding the role of autophagy in sepsis-induced acute lung injury (ALI) may provide …
Understanding the role of autophagy in sepsis-induced acute lung injury (ALI) may provide …
[HTML][HTML] Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy
Q Miao, LL Bi, X Li, S Miao, J Zhang, S Zhang… - International journal of …, 2013 - mdpi.com
The traditional Chinese medicine bufalin, extracted from toad's skin, has been demonstrated
to exert anticancer activities in various kinds of human cancers. The mechanisms of action …
to exert anticancer activities in various kinds of human cancers. The mechanisms of action …
[HTML][HTML] Potential effects of allyl isothiocyanate on inhibiting cellular proliferation and inducing apoptotic pathway in human cisplatin-resistant oral cancer cells
Background/purpose Cisplatin-resistant oral cancer is clinically difficult to manage and the
dose-dependent toxicities of cisplatin has been widely concerned. Allyl isothiocyanate …
dose-dependent toxicities of cisplatin has been widely concerned. Allyl isothiocyanate …