The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

The major function of vitamin D in vertebrates is maintenance of calcium homeostasis, but
vitamin D insufficiency has also been linked to an increased risk of hypertension …

Cholesterol homeostasis is critical for normal growth and development. In addition to being
a major membrane lipid, cholesterol has multiple biological functions. These roles include …

The role of lipids in providing energy and structural cellular components during vertebrate
development is poorly understood. To elucidate these roles further, we visualized lipid …

Potatoes (Solanum tuberosum) contain α-solanine and α-chaconine, two well-known toxic
steroidal glycoalkaloids (SGAs). Sprouts and green tubers accumulate especially high levels …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Cholesterol is an essential substance involved in many functions, such as maintaining cell
membranes, manufacturing vitamin D on surface of the skin, producing hormones, and …

Sterol synthesis is required for Sonic hedgehog (Shh) signal transduction. Errors in Shh
signal transduction play important roles in the formation of human tumors, including …

Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …

Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …