Liver X receptors in lipid metabolism: opportunities for drug discovery
C Hong, P Tontonoz - Nature reviews Drug discovery, 2014 - nature.com
The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …
transcription factors control the expression of a battery of genes involved in the uptake …
Vitamin D in plants: a review of occurrence, analysis, and biosynthesis
RB Jäpelt, J Jakobsen - Frontiers in plant science, 2013 - frontiersin.org
The major function of vitamin D in vertebrates is maintenance of calcium homeostasis, but
vitamin D insufficiency has also been linked to an increased risk of hypertension …
vitamin D insufficiency has also been linked to an increased risk of hypertension …
Malformation syndromes caused by disorders of cholesterol synthesis
FD Porter, GE Herman - Journal of lipid research, 2011 - ASBMB
Cholesterol homeostasis is critical for normal growth and development. In addition to being
a major membrane lipid, cholesterol has multiple biological functions. These roles include …
a major membrane lipid, cholesterol has multiple biological functions. These roles include …
Zebrafish embryonic lipidomic analysis reveals that the yolk cell is metabolically active in processing lipid
The role of lipids in providing energy and structural cellular components during vertebrate
development is poorly understood. To elucidate these roles further, we visualized lipid …
development is poorly understood. To elucidate these roles further, we visualized lipid …
Sterol side chain reductase 2 is a key enzyme in the biosynthesis of cholesterol, the common precursor of toxic steroidal glycoalkaloids in potato
S Sawai, K Ohyama, S Yasumoto, H Seki… - The Plant …, 2014 - academic.oup.com
Potatoes (Solanum tuberosum) contain α-solanine and α-chaconine, two well-known toxic
steroidal glycoalkaloids (SGAs). Sprouts and green tubers accumulate especially high levels …
steroidal glycoalkaloids (SGAs). Sprouts and green tubers accumulate especially high levels …
[图书][B] Handbook of vitamins
J Zempleni, JW Suttie, JF Gregory III, PJ Stover - 2013 - books.google.com
Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …
edition of a bestseller presents comprehensive summaries that analyze the chemical …
[HTML][HTML] Lipoproteins, cholesterol homeostasis and cardiac health
TF Daniels, KM Killinger, JJ Michal… - … journal of biological …, 2009 - ncbi.nlm.nih.gov
Cholesterol is an essential substance involved in many functions, such as maintaining cell
membranes, manufacturing vitamin D on surface of the skin, producing hormones, and …
membranes, manufacturing vitamin D on surface of the skin, producing hormones, and …
Cholesterol–the devil you know; ceramide–the devil you don't
TS Tippetts, WL Holland, SA Summers - Trends in pharmacological …, 2021 - cell.com
Ectopic lipids play a key role in numerous pathologies, including heart disease, stroke, and
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …
diabetes. Of all the lipids studied, perhaps the most well understood is cholesterol, a widely …
Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies
B Roskams-Hieter, HJ Kim, P Anur, JT Wagner… - NPJ Precision …, 2022 - nature.com
Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …
cancer and the systemic host response. Here we report that cfRNA sequencing enables the …
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
RB Corcoran, MP Scott - Proceedings of the national …, 2006 - National Acad Sciences
Sterol synthesis is required for Sonic hedgehog (Shh) signal transduction. Errors in Shh
signal transduction play important roles in the formation of human tumors, including …
signal transduction play important roles in the formation of human tumors, including …