Unveiling therapeutic potential: Adipose tissue-derived mesenchymal stem cells and their exosomes in the management of diabetes mellitus, wound healing, and …

A Ahmadieh-Yazdi, M Karimi, E Afkhami… - Biochemical …, 2024 - Elsevier
Diabetes mellitus (DM) is a pervasive global health issue with substantial morbidity and
mortality, often resulting in secondary complications, including diabetic wounds (DWs) …

Biomimetic scaffolds loaded with mesenchymal stem cells (MSCs) or MSC-derived exosomes for enhanced wound healing

A Ghasempour, H Dehghan, M Mahmoudi… - Stem Cell Research & …, 2024 - Springer
Since wound healing is one of the most important medical challenges and common
dressings have not been able to manage this challenge well today, efforts have been …

Engineered Enucleated Mesenchymal Stem Cells Regulating Immune Microenvironment and Promoting Wound Healing

Z Chen, Y Zou, H Sun, Y He, K Ye, Y Li… - Advanced …, 2024 - Wiley Online Library
Persistent excessive inflammation caused by neutrophil and macrophage dysfunction in the
wound bed leads to refractory response during wound healing. However, previous studies …

Exosomes derived from adipose stem cells in combination with hyaluronic acid promote diabetic wound healing

H Huldani, IA Kozlitina, M Alshahrani, HMA Daabo… - Tissue and Cell, 2023 - Elsevier
Diabetic wound is one of the main challenges in dermatology. Although stem cell-based
treatment has therapeutic benefits in wound repair, the clinical application is still limited …

Amnion-derived hydrogels as a versatile platform for regenerative therapy: from lab to market

G Kafili, H Niknejad, E Tamjid, A Simchi - Frontiers in Bioengineering …, 2024 - frontiersin.org
In recent years, the amnion (AM) has emerged as a versatile tool for stimulating tissue
regeneration and has been of immense interest for clinical applications. AM is an abundant …

Three-dimensional bioengineered dermal derived matrix scaffold in combination with adipose-derived stem cells accelerate diabetic wound healing

F Bour, S Khalilollah, M Omraninava, MS Mirzaie… - Tissue and Cell, 2024 - Elsevier
Due to the multifactorial nature of diabetic wounds, the most effective treatments require
combinatorial approach. Herein we investigated whether engraftment of a bioengineered …

Preclinical and Clinical Studies on the Use of Extracellular Vesicles Derived from Mesenchymal Stem Cells in the Treatment of Chronic Wounds

S Rezaei, MA Nilforoushzadeh… - Molecular …, 2024 - ACS Publications
To date, the widespread implementation of therapeutic strategies for the treatment of chronic
wounds, including debridement, infection control, and the use of grafts and various …

Decellularized human amniotic membrane loaded with epigallocatechin-3-gallate accelerated diabetic wound healing

F Azimi-Bahnamiri, H Mokhtari, S Khalilollah… - Journal of Tissue …, 2024 - Elsevier
Diabetic wounds, as one of the most important complications of diabetes, face many
challenges in treatment. Herein we investigated whether decellularized human amniotic …

Transplantation of bioengineered dermal derived matrix-scaffold in combination with hyperbaric oxygen therapy improves wound healing in diabetic rats

AR Khalatbary, S Sarabandi, F Ahmadi, FM Kasmaie… - Tissue and Cell, 2024 - Elsevier
Successful treatment of diabetic wounds requires multifactorial approaches. Herein we
investigated the effects of a bioengineered three-dimensional dermal derived matrix-scaffold …

Therapeutic potential of adipose-derived stem cell extracellular vesicles: from inflammation regulation to tissue repair

B Zhou, Q Chen, Q Zhang, W Tian, T Chen… - Stem Cell Research & …, 2024 - Springer
Inflammation is a key pathological feature of many diseases, disrupting normal tissue
structure and resulting in irreversible damage. Despite the need for effective inflammation …