An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies
Red blood cell (RBC) aging in the blood bank is characterized by the accumulation of a
significant number of biochemical and morphologic alterations. Recent mass spectrometry …
significant number of biochemical and morphologic alterations. Recent mass spectrometry …
Quantifying dynamic range in red blood cell energetics: Evidence of progressive energy failure during storage
SC Rogers, X Ge, M Brummet, X Lin, DD Timm… - …, 2021 - Wiley Online Library
Background During storage, red blood cells (RBCs) undergo significant biochemical and
morphologic changes, referred to collectively as the “storage lesion”. It was hypothesized …
morphologic changes, referred to collectively as the “storage lesion”. It was hypothesized …
Erythrocyte storage in hypertonic (SAGM) or isotonic (PAGGSM) conservation medium: influence on cell properties
L Zehnder, T Schulzki, JS Goede, J Hayes… - Vox …, 2008 - Wiley Online Library
Background and Objectives Prolonged red blood cell (RBC) storage may be associated with
increased post‐transfusion morbidity and mortality. A contributing factor is RBC storage …
increased post‐transfusion morbidity and mortality. A contributing factor is RBC storage …
Storage-induced damage to red blood cell mechanical properties can be only partially reversed by rejuvenation
G Barshtein, A Gural, N Manny, O Zelig… - Transfusion medicine …, 2014 - karger.com
Background: The storage of red blood cells (RBC) is associated with impairment of their
properties that can induce a circulatory risk to recipients. In a preceding study (2009), we …
properties that can induce a circulatory risk to recipients. In a preceding study (2009), we …
[HTML][HTML] Membrane remodelling and vesicle formation during ageing of human red blood cells
Background/Aims: A high surface-to-volume ratio and a spectrin membrane-skeleton (MS)
confer to the mammalian red blood cells (RBCs) their characteristic deformability …
confer to the mammalian red blood cells (RBCs) their characteristic deformability …
Rejuvenation treatment of stored red blood cells reverses storage‐induced adhesion to vascular endothelial cells
A Koshkaryev, O Zelig, N Manny, S Yedgar… - …, 2009 - Wiley Online Library
BACKGROUND: Blood banking procedures are associated with elevated adherence of red
blood cells (RBCs) to blood vessel wall endothelial cells (ECs), which can introduce a …
blood cells (RBCs) to blood vessel wall endothelial cells (ECs), which can introduce a …
[HTML][HTML] Spectrin and other membrane-skeletal components in human red blood cells of different age
Background: Old human red blood cells (RBCs) have a reduced surface area with respect to
young RBCs. If this decrease occurred through the release of vesicles similar to the spectrin …
young RBCs. If this decrease occurred through the release of vesicles similar to the spectrin …
[HTML][HTML] Mechanism of faster NO scavenging by older stored red blood cells
The blood storage lesion involves morphological and biochemical changes of red blood
cells (RBCs) that occur during storage. These include conversion of the biconcave disc …
cells (RBCs) that occur during storage. These include conversion of the biconcave disc …
The effects of long‐term storage of human red blood cells on the glutathione synthesis rate and steady‐state concentration
S Whillier, JE Raftos, RL Sparrow, PW Kuchel - Transfusion, 2011 - Wiley Online Library
BACKGROUND: Banked red blood cells (RBCs) undergo changes that reduce their viability
after transfusion. Dysfunction of the glutathione (GSH) antioxidant system may be implicated …
after transfusion. Dysfunction of the glutathione (GSH) antioxidant system may be implicated …
The effects of blood transfusion on red blood cell distribution width in critically ill patients: a pilot study
S Spadaro, FS Taccone, A Fogagnolo, F Franchi… - …, 2018 - Wiley Online Library
BACKGROUND Red blood cell distribution width (RDW) is a measure of anisocytosis,
generally used in the differential diagnosis of anemia. Recently, RDW was associated with …
generally used in the differential diagnosis of anemia. Recently, RDW was associated with …