Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

Death is the inevitable fate of all living organisms, whether at the individual or cellular level.
For a long time, cell death was believed to be an undesirable but unavoidable final outcome …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that
has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …