Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Recently, mesenchymal stromal cells (MSCs) and their derivative exosome have become a
promising approach in the context of liver diseases therapy, in particular, acute liver failure …

Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs)
and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and …

Intervertebral disc degeneration (IDD) is a common disease that increases with age, and its
occurrence is stressful both psychologically and financially. Stem cell therapy for IDD is …

Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases due to
the roles of MSCs in regeneration, fibrosis inhibition and immune regulation. However, the …

Liver fibrosis is a common result of most chronic liver diseases, and advanced fibrosis often
leads to cirrhosis. Currently, there is no effective treatment for liver cirrhosis except liver …

Pathologies of the vasculature including the microvasculature are often complex in nature,
leading to loss of physiological homeostatic regulation of patency and adequate perfusion to …

The liver is a vital organ responsible for metabolic and digestive functions, protein synthesis,
detoxification, and numerous other necessary functions. Various acute, chronic, and …

Simple Summary We define the transcriptome and secretome of primary LSECs during the
progression of cirrhosis, revealing specific molecular signatures, novel biomarkers and …

Abstract Purpose of Review Portal hypertension is responsible of the main complications of
cirrhosis, which carries a high mortality. Recent treatments have improved prognosis, but …